1 Lee YA,Wallace MC,Friedman SL.Pathobiology of liver fibrosis:a translational success story. Gut,2015,64:830-841.
2 Ismail MH,Pinzani M.Reversal ofliver fibrosis.Saudi JGastroenterol,2009,15:72-79.
3 Tu X,Zhang H,Zhang J,et al.Micro RNA-101 suppresses liver fibrosis by targeting the TGFbeta signalling path way. JPathol,2014,234:46-59.
4 Fried man SL. Hepatic stellate cells:protean,Multifunctional,and enig matic cells of the liver. Physiol Rev,2008,88:125-172.
5 Tu X,Zheng X,Li H,et al.micro RNA-30 protect against CCl4-induced liver fibrosis by attenuating TGF-beta signaling in hepatic stellate cells. Toxicol Sci,2015,146:157-169.
6 Teixeira-Clerc F,Julien B,Grenard P,et al.CB1 cannabinoid receptor antagonism:a new strategy for the treatment of liver fibrosis. Nat Med,2006,12:671-676.
7 Mallat A,Teixeira-Clerc F,Lotersztajn S.Cannabinoid signaling and liver therapeutics.JHepatol,2013,59:891-896.
8 Chen SW,Wu BY,Xu SP,et al.Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNAa meliorates hepatic fibrosis in rats. PLoSOne,2012,7:e50850.
9 Wei Y,Kang XL,Wang X.The peripheral cannabinoid receptor 1 antagonist VD60 efficiently inhibits carbon tetrachlorideintoxicated hepatic fibrosis progression. Exp Biol Med (May wood),2014,239:183-192.
10 Granzow M,Schierwagen R,Klein S,et al.Angiotensin-IItype 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology,2014,60:334-348.
11 Rozenfeld R,Gupta A,Gagnidze K,et al.AT1 R-CB(1)Rhetero Merization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBOJ,2011,30:2350-2363.
12 Hong F,Chou H,Fiel MI,et al.Antifibrotic activity of sorafenib in experimental hepatic fibrosis:refinement of inhibitory targets,dosing,and window of efficacy in vivo. Dig Dis Sci,2013,58:257-264.
13 Kuo WL,Yu MC,Lee JF,et al.Imatinib mesylate im proves liver regeneration and attenuatesliver fibrogenesisin CCl4-treated mice. JGastrointest Surg,2012,16:361-369.
14 Hem mann S,Graf J,Roderfeld M,et al. Expression of MMPs and TIMPs in liver fibrosis -a systematic review with special em phasis on anti-fibrotic strategies.JHepatol,2007,46:955-975.
15 Elsharkawy AM,Oakley F,Mann DA.The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis,2005,10:927-939.
16 Arendt E,Ueberha MU,Bittner R,et al.Enhanced Matrix degradation after withdrawal of TGF-beta1 triggers hepatocytes fro Mapoptosis to proliferation and regeneration. Cell Prolif,2005,38:287-299.
17 Murphy FR,Issa R,Zhou X,et al.Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition:im plications for reversibility of liver fibrosis.JBiol Chem,2002,277:11069-11076.
18 Cong M,Liu T,Wang P,et al.Suppression of tissue inhibitor of metalloproteinase-1 by recombinant adeno-associated viruses carrying siRNAsin hepatic stellate cells.Int JMol Med,2009,24:685-692.
19 Cong M,Liu T,Wang P,et al.Antifibrotic effects of a recombinant adeno-associated virus carrying small interfering RNAtargeting TIMP-1 in rat liver fibrosis. AMJPathol,2013,182:1607-1616.
20 Barry-Ha milton V,Spangler R,Marshall D,et al. Allosteric inhibition of lysyl oxidase-like-2 im pedes the develop ment of a pathologic microenviron ment. Nat Med,2010,16:1009-1017.
21 Spahl DU,Berendji-Grun D,Suschek CV,et al.Regulation of zinc ho meostasis by inducible NOsynthase-derived NO:nuclear metallothionein translocation and intranuclear Zn2+release. Proc Natl Acad Sci USA,2003,100:13952-13957.
22 Jiang Y,Kang YJ.Metallothionein gene therapy for chemicalinduced liver fibrosis in mice. Mol Ther,2004,10:1130-1139.
23 Xu X,Shi F,Huang W,et al.Metallothionein gene transfection reverses the phenotype of activated hu man hepatic stellate cells.JPharmacol Exp Ther,2013,346:48-53.
24 Zhao YY,Takahashi M,Gu JG,et al.Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Cancer Sci,2008,99:1304-1310.
25 Liu J,Zhang Z,Tu X,et al.Knockdow n of N-acetylglucosa minyl transferase Va meliorates hepatotoxin-induced liver fibrosis in mice. Toxicol Sci,2013,135:144-155.
26 Chakraborty JB,Mann DA.NF-kappaBsignalling:e Mbracing complexity to achieve translation.JHepatol,2010,52:285-291.
27 Bansal R,Prakash J,Post E,et al.Novel engineered targeted interferon-ga Mma blocks hepatic fibrogenesisin mice. Hepatology,2011,54:586-596. |
