A meta-analysis of comparison of efficacy of tenofovir or entecavir in nucleos(t)ide analogue-naive patients with chronic hepatitis B

Abstract

Abstract: Objective To compare treatment efficacy and safety of tenofovir (TDF) or entecavir (ETV) in nucleoside-nave chronic hepatitis B (CHB) patients using meta-analysis.Methods Published data relevant to TDF or ETV treated CHB patients from January 2006 to October 2016 was enrolled and meta-analyzed. The rate of Hepatitis B virus (HBV) DNA suppression, alanine transaminase (ALT) normalization, and hepatitis B e antigen (HBeAg) seroconversion at week 48 and 96 were reviewed, respectively. Drug safety and resistance were also discussed.Results There were 6 articles involved. The meta-analysis showed no significant differences in HBV DNA suppression rate between the two drugs innave treated CHB patients (TDF vs. ETV: RR= 1.19, 95% CI = 1.09~1.30 and RR=1.08, 95% CI=1.02~1.14 for week 48 and week 96, respectively). Moreover, there were also no differences in ALT normalization rate (4 studies for 48 weeks), HBeAg seroconversion rate (3 studies for 96 weeks) and long-term safety between TDF and ETV, respectively.Conclusion TDF and ETV show similar efficacy in treating nucleoside-nave chronic HBV patients. Nevertheless, the long-term efficacy and safety should be monitored in prolonged therapy.

Key words: Chronic hepatitis B, Entecavir, Tenofovir disoproxil fumarate, Meta-analysis

DING Rong-rong, SHI Guang-feng, ZHANG Zhan-qing, ZHOU Xin-lan. A meta-analysis of comparison of efficacy of tenofovir or entecavir in nucleos(t)ide analogue-naive patients with chronic hepatitis B[J]. Chinese Hepatolgy, 2017, 22(5): 400-403.

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