Abstract: Objective To study the risk factors for liver dysfunction after liver resection for hepatocellular carcinoma (HCC).Methods The clinical data of 198 HCC patients admitted to our hospital from April 2017 to July 2019 who received hepatectomy were retrospectively analyzed. The retention rate of indocyanine green at 15 minutes (ICG-R15), serum albumin (ALB) before surgery, and postoperative liver function were recorded. Multivariate logistic regression was used to analyze the independent risk factors for liver dysfunction after liver resection for HCC. Results All the 198 patients underwent hepatectomy successfully, and 60 patients (30.30%) had hepatic dysfunction after operation. Multivariate logistic regression analysis showed that ALB [odd ratio (OR)=1.752, 95% confidence interval (CI) = 1.113-2.758], ICG-R15 (OR=1.136, 95% CI = 1.026-1.258), hepatic portal occlusion time (OR=1.129, 95% CI = 1.002-1.272), resected liver volume (OR=2.118, 95% CI = 1.070-4.192), and operation time (OR=1.007, 95% CI = 1.001-1.013) were independent risk factors for postoperative liver dysfunction (P<0.05).Conclusion Liver dysfunction after liver resection for HCC is associated with high preoperative ICG-R15, low serum ALB level, long time of hepatic portal occlusion and operation, and large resected liver volume.

Key words: Primary hepatocellular carcinoma, Hepatectomy, Liver dysfunction, Indocyanine green clearance test, Hepatic portal occlusion time