Abstract: Objective To investigate the clinical features, diagnostic methods and treatments of hepatic sinusoidal obstruction syndrome (HSOS) induced by gynura segetum. Methods In this retrospective cohort study, clinical data of 20 gynura segetum-induced HSOS patients from November 2011 to December 2015 in our hospital was collected. Results Most patients were the elderly, and developed in subacute onset within 4 months since receiving gynura segetum. Among all 20 cases, initial symptom was abdominal distension, and results of abdominal CT or MRI examination showed map-like density changes with narrowing or invisible hepatic veins. There was 1 case occurred with hepatomegaly and no ascites, while the other 19 cases had ascites. It showed no significant difference in liver injury between patients with or without drinking history. All patients received clinical therapy after hospitalized, 1 case was cured, and 7 cases were improved including 2 received transjugular intrahepatic portosystemic shunt. Conclusion Gynura segetum can cause HSOS, which shows characteristic performance in CT or MRI and can be improved by early anticoagulation and microcirculation therapy. Furthermore, hepatotoxicity of gynura segetum deserves more attention.

Key words: Hepatic sinusoidal obstruction syndrome, Gynura segetum, Liver injury