Abstract: Objective To investigate safety and efficacy of radiofrequency endometrial ablation operation for abnormal uterine bleeding in liver cirrhosis.Methods Twenty six patients with cirrhosis and abnormal uterine bleeding in our hospital from April 2012 to May 2015 were enrolled, and received radiofrequency endometrial ablation operation. Results The procedures was completed successfully in all the patients.The mean operation time was (61.0±18.9)s (ranged from 37 to 108 s).During the operation, the blood loss was less than 15m1, no complications occurred.No significant difference of variables related to liver disease between variables obtained at 1 month post-NovaSure treatment with those obtained at baseline in the cirrhotic(P> 0.05). There are significant improvement of anemia, fatigue, dysphoria and QoL scores was observed at after the therapy compared to those at baseline (P< 0.001). The rate of amenorrhoea was 88.5％(23/26)、95.2％(20/21)、100％(19/19) and 92.9%(13/14), and the rate of efficacy satisfaction was 100％(26/26)、100％(21/21)、100％(19/19) and 100(14/14), and the satisfaction rates was 100％、100％、100％ and 92.31% at months 1,3,6, and 12, respectively.Conclusion Radiofrequency endometrial ablation operation shows good efficacy and safety in the treatment of abnormal uterine bleeding in patients with liver cirrhosis.

Key words: Radiofrequency endometrial ablation, Cirrhosis, Abnormal Uterine Bleeding(AUB), Safety and Efficacy