Abstract: Objective To evaluate the clinical application of dual-energy iodine and magnetic resonance diffusion-weighted imaging (DWI) in the evaluation of interventional transcatheter arterial chemoembolization (TACE) therapy against primary liver cancer. Methods 106 patients with liver cancer diagnosed in Jianghan Oilfield General Hospital from January 2017 to October 2018 were enrolled. The upper abdominal magnetic resonance DWI and dual energy scan were performed in all patients before and after TACE therapy. The apparent dispersion coefficient (ADC) values of preoperative and postoperative lesions were measured. The ADC values were transferred to the Liver VNC post-processing software to evaluate the positive detection rate of the lesions. Results The ADC values of the liver cancer tissues after TACE therapy were significantly higher than those before operation (P<0.05). The ADC values of the lesions were highest at 15 days after surgery, which was in line with the peak time of tumor cells necrosis. The ADC values decreased after 28d post operation. 102 lesions were confirmed by digital subtraction angiography (DSA), and the positive detection rate of the lesion was 97.17%. Both the positive detection rate and the sensitivity were high. Conclusion Dual-energy iodine in combine with magnetic resonance DWI can effectively evaluate the survival and necrosis of liver cancer after interventional TACE therapy, avoid the interference of iodized oil artifacts, and detect intrahepatic lesions, which has important significance for guiding further treatment.

Key words: Dual energy iodine map, Magnetic resonance diffusion-weighted imaging, Liver cancer, Interventional transcatheter arterial chemoembolization therapy