Abstract: Objective To explore the composition and changes of disease spectrum of patients with liver diseases in Pudong New Area Nanhua Hospital in recent five years. To provide reference for the treatment of patients with liver diseases and the development and construction of specialized hospitals for liver diseases. Methods It was a retrospective study of the disease composition of the inpatients with liver disease in our hospital from January 2015 to December 2019. According to the annual statistics of the number of inpatients with various liver diseases, we compared the composition of infectious and non-infective liver diseases, and analyzed the dynamic changes of the composition of liver disease in the past five years. Results The percentage of infective liver disease was decreasing year by year, but it was still the main cause of liver disease hospitalization, among which chronic hepatitis B was still the first cause. The incidence of non-infective liver disease continues to rise, among which non-alcoholic fatty liver disease was the first. Conclusion The number of inpatients with infective liver disease were declining, and non-infective liver disease were on the rise. The construction and development of liver disease specialist hospital may need multidisciplinary cross cooperation.

Key words: Hepatitis disease, Spectrum, Constituent ratio