Abstract: Objective To study the clinical characteristics of transfusion and non transfusion chronic hepatitis C virus (HCV) infection. Methods The clinical dataes of 84 patients with HCV infection were analyzed retrospectively,which accorded to the principle of parallel control trial.There were 42 cases were infected by blood transfusion among them, which was the observation group.The other 42 cases were non blood transfusion HCV infection, which was the control group.The basic demographic dataes and pathological characteristics of the two groups were compared, and the clinical characteristics of the patients with HCV infection were recorded. Results The age of patients in the observation group was significantly higher than that in the control group,the difference was statistically significant (P<0.05).There were no significant difference in gender, BMI, occupation and education between the two groups (P>0.05).The course of disease in the observation group was longer than that in the control group,the difference was statistically significant (P<0.05).There was significant difference in the distribution of HCV genotypes between the two groups (P<0.05).There was no significant difference in HCV load between the two groups (P>0.05). Conclusion There are significant differences in genotype distribution among patients with different routes of HCV infection.The patients who infected by blood transfusion has longer course of disease and the age is older.

Key words: Chronic hepatitis C with blood transfusion, Clinical characteristics, Infection