Chinese Hepatolgy ›› 2020, Vol. 25 ›› Issue (11): 1188-1190.

• Liver Fibrosis & Cirrhosis • Previous Articles     Next Articles

Effect of microecological preparation on intestinal barrier function in patients with cirrhosis and spontaneous peritonitis

YANG Xiao-dong1, YU Ming-li2, JIA Ting1, ZHANG Xiu-ling1, GAO Si-yuan1, YU Xiang-qiong1, WANG Li-ping1, SHI Jun1   

  1. 1. Two subjects of liver diseases,2. Department of Pharmacy,Kunming Third People's Hospital,Yunnan 650041,China
  • Received:2020-02-18 Online:2020-11-30 Published:2020-12-22
  • Contact: YU Xiang-qiong,Email:41660380@qq.com

Abstract: Objective To investigate the effect of microecological preparation on intestinal barrier function in patients with cirrhosis and spontaneous peritonitis (SBP).Methods A total of 80 patients with cirrhosis and SBP admitted to our hospital from May 2015 to May 2019 were divided into control group and observation group according to random number table.The control group was given routine treatment,the observation group was given microecological preparation in addition to routine treatment,and the course of treatment in both groups was 2 weeks.Clinical efficacy of the 2 groups was compared.Two ml venous blood was collected before and 2 weeks after treatment,respectively.Serum endotoxin (ET),procalcitonin (PCT),hypersensitive c-reactive protein (CRP),and interleukin-6 (IL-6) levels were detected in the 2 groups,to indirectly reflect changes of intestinal barrier function.Results The total effective rate of the observation group was 95.00%,higher than 80.00% of the control group,and the difference was statistically significant (P<0.05).After treatment,the levels of serum ET,PCT,CRP and IL-6 in both groups were lower than those before treatment,and the levels in the observation group were significantly lower than those in the control group (P<0.05).The adverse reaction rate was 7.50% in the observation group and 5.00%in the control group,with no significant difference (P>0.05).The complication rate was 5.00% in the observation group and 10.00% in the control group,with no significant difference (P>0.05).Conclusion Compared with the conventional treatment in patients with cirrhosis and SBP,the addition of microecological agents can promote intestinal barrier function and improve the curative effect,with high value of clinical application.

Key words: Cirrhosis, Spontaneous peritonitis, Microecological preparation, Intestinal barrier function, Complication