Abstract: Objective To investigate and analysis SF-36 and The General Self-efficacy scale(GSES) which can explore quality of life and clinical outcomes of patients with primary biliary cholangitis (PBC) in different groups.Methods A analysis was performed for 215 patients with PBC who were admitted to The Second Affiliated Hospital of the Baotou Medical College form March 2015 to July 2019.Fourtyfive cases who made physical examination were randomly selected as a control.The patients with PBC who were divided into three groups with the Child classification,and the association between SF-36,GSES and the quality of life,confidence and self-control were analyzed.The t test was used for comparison between two groups.When P<0.05 means there is a difference between the two to be compared,P<0.01 means there are significant differences.Results SF-36 and GSES scores of three groups of patients with PBC compared with normal control group.SF-36,GSES scores of PBC patients in group Child A were higher than the control group,P<0.05.The score of group Child B compared with the control group with no difference,P>0.05.the score of PBC patients in group Child C were lower than the control group,P<0.01.Conclusion Patients with PBC have great mood swings during disease progression.From the Child A group with high mood,to the Child C group's depression,which were all involved in disease development.Mood changes can change the vascular endothelial function involved in the occurrence and development of liver disease,which deserves deeper and more systematic research.We suggested that medical workers may pay more attention to the patients' moods in the clinical work in the future.If the patients were found in high spirits or low spirits,they should be timely guided and corrected,and prevent the disease occuprogress.

Key words: Primary biliary cholangitis, patient reported outcomes, SF-36, The General Self-efficacy scale