Chinese Hepatolgy ›› 2020, Vol. 25 ›› Issue (12): 1258-1261.

• Liver Failure • Previous Articles     Next Articles

The role of serum markers in predicting the prognosis and clinical outcome of liver failure caused by various etiologies

LUO Wan-rong1, XU Yu-min2, CHEN Xue-bing1, CHEN Gao1, SHI Dong-mei2, XIE Qing2   

  1. 1. Department of Infection,People's Hospital of Deyang City,Sichuan 618000,China;
    2. Department of Infection, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China
  • Received:2020-06-04 Online:2020-12-31 Published:2021-02-26
  • Contact: XU Yu-min,Email:xym121@163.com

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Abstract: Objective To investigate the predictive value of serum prealbumin level, neutrophil lymphocyte ratio (NLR), and MELD-Na score on the outcome of patients with early stage of liver failure induced by various etiologies.Methods 100 patients with liver failure due to various etiologies were studied. The clinical data of patients were retrospectively collected. The patients were divided into improved group (51 cases) and poor prognosis group (49 cases) based on their clinical outcomes. The levels of serum prealbumin, neutrophil lymphocyte ratio (NLR) and MELD-Na score at admission were compared between these two groups. The association between these indicators with the early prognosis of the disease was analyzed. T-test was used for the measurement data and χ2 test was used for counting data. Correlation analysis was performed with SPSS 25.0 software. P<0.05 was considered statistically significant.Results Serum prealbumin level in the improved group at admission was significantly higher than that in the poor prognosis group (65.08 vs 51.02, P<0.05). The neutrophil and lymphocyte ratio (NLR) and MELD-Na score were significantly lower than those in the poor prognosis group (4.00 vs 5.69, 21.40 vs 28.02, P<0.05). There were significant differences in stratification analysis of serum prealbumin, neutrophil lymphocyte ratio (NLR) and MELD-Na score between the improvement group and the poor prognosis group (P<0.05).Conclusion Serum prealbumin, neutrophil lymphocyte ratio (NLR) and MELD-Na score are associated with the prognosis. Early assessment can help to early predict the prognosis of liver failure with accuracy.

Key words: Liver failure, Serum prealbumin, Neutrophil to lymphocyte ratio (NLR), MELD-Na score, Prognosis