Abstract: Objective To investigate the early effect of three-dimensional conformal radiotherapy on liver cancer patients with transcatheter arterial chemoembolization (TACE).Methods One hundred and twenty-four patients with advanced primary liver cancer were retrospectively selected in this study, They were divided into combined group (n=56) and simple TACE group (n=68) according to the treatment they had received. The early clinical efficacy, adverse reactions, and survival rate were observed in 1-year's follow-up period of time.Results The early effective rate of the combined group was higher than that of the TACE group (73.21% vs 52.94%, P<0.05). The incidence of total toxicity and side effects during radiotherapy in the combined group was 33.93%, including 1 case (1.79%) of acute radiation gastritis, 1 case (1.79%) of acute radiation liver injury, 1 case (1.79%) of leucocytes count lower than 2.5×10⁹/L. There was no significant difference in overall survival rate between the two groups at 1 year after the treatment (P>0.05).Conclusion For patients with advanced liver cancer, TACE combined with three-dimensional conformal radiotherapy can effectively improve the early clinical efficacy, without severe radiotherapy toxicity and side effects.

Key words: 3D conformal radiotherapy, Radiation therapy, Liver cancer, Transcatheter arterial chemoembolization, Clinical effect