The value of liver magnetic resonance imaging in combination with serum biomarkers for the diagnosis of hepatocellular carcinoma

Abstract

Abstract: Objective To explore the diagnostic value of combining Magnetic Resonance Imaging (MRI) with serum levels of Dikkopf-1(DKK1), glypican-3(GPC3), FOXP3 and CXCL13 for patients with hepatocellular carcinoma(HCC).Methods Eighty hospitalized patients with HCC aged 30-75 were selected in HCC group. Sixty patients with chronic hepatitis and cirrhosis were enrolled as chronic liver diseases (CLD) group. Sixty healthy people were enrolled in the control group. All patients in the three groups were examined by MRI, and detected with serum levels of DKK1, GPC3, FOXP3, CXCL13, and AFP by enzyme linked immunosorbent assay (ELISA). The positive rate, sensitivity and specificity of each parameters were calculated and compared.Results The serum levels of four biomarkers in HCC group and CLD group were higher than those in the control group, and the levels in HCC group were higher than those in the CLD group (P<0.05). The sensitivity of MRI and serum levels of DKK1, GPC3, FOXP3 and CXCL13 for the diagnosis of HCC were 88.8%,95.0%,91.3%,85.0%,93.7%,respectively,and all were higher than 80%. The specificity of them were 76.7%,85.0%,80.0%,71.7%,81.7%,respectively, and all were higher than 70%. Among them, the sensitivity and specificity of DK1 were the highest (95.0% and 85.0%,respectively). The sensitivity and specificity of AFP (81.3% and 56.7%, respectively)for the diagnosis of HCC were lower when compared with these biomarkers.Conclusion MRI in combination with serum detection of DKK1, GPC3, FOXP3 and CXCL13 may improve the detection rate of HCC, and has a high clinical application value.

Key words: Hepatocellular carcinoma, Diagnosis, Magnetic Resonance Imaging, Serum biomarkers

FENG Shuo, ZAN Li-shan, MA Jun, LI Fan, JIA Jian-wei, LI Zeng-jun. The value of liver magnetic resonance imaging in combination with serum biomarkers for the diagnosis of hepatocellular carcinoma[J]. Chinese Hepatolgy, 2020, 25(12): 1282-1285.

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