Abstract: Objective To investigate the influence of preventive anticoagulation timing on the risk of postoperative venous thrombosis in patients with hepatitis B cirrhosis, portal hypertension and hypersplenism.Methods Sixty-eight patients with liver cirrhosis, portal hypertension and hypersplenism were included as the research objects, and divided into the observation group (n=34) and the control group (n=34) using a random number table. The observation group received anticoagulation intervention during the operation, and the control group received anticoagulation intervention 2 days after the operation. The baseline characteristics of the 2 groups were recorded. The incidence of postoperative venous thrombosis and the levels of 4 coagulation indices were comparatively analyzed between the 2 groups.Results The incidence of postoperative venous thrombosis in the observation group was lower than that in the control group (P<0.05). The thrombus severity had no significant difference between the 2 groups (P>0.05), as did the bleeding volume during the operation and postoperative extubation time (all P>0.05). The operation time of the observation group was significantly longer than that of the control group, and the postoperative hospital stay was significantly shorter than that of the control group (both P<0.05). The prothrombin time, activated partial thromboplastin time and thrombin time in the observation group were significantly longer than those in the control group, the fibrinogen was significantly lower than that in the control group (all P<0.05).Conclusion In patients with liver cirrhosis, portal hypertension and hypersplenism, the effect of anticoagulation during the operation is better than 2 days after the operation, which is helpful to reduce the incidence of postoperative venous thrombosis.

Key words: Preventive anticoagulation, Hepatitis B cirrhosis, Portal hypertension, Hypersplenism, Venous thrombosis