[1] Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet,2018,391:1301-1314. [2] Greenhill C. Liver cancer: Different effects of the Notch receptors in liver cancer revealed. Nat Rev Gastroenterol Hepatol, 2014,11:703. [3] Bigas A, Espinosa L. The multiple usages of Notch signaling in development, cell differentiation and cancer. Curr Opin Cell Biol, 2018,55:1-7. [4] Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell,2009,137:216-233. [5] Andersen P, Uosaki H, Shenje LT, et al. Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol,2012,22:257-265. [6] Nowell CS, Radtke F. Notch as a tumour suppressor. Nat Rev Cancer 2017;17:145-159. [7] Ranganathan P, Weaver KL, Capobianco AJ. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer,2011,11:338-351. [8] Moore G, Annett S, McClements L, et al. Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives. Cells,2020,9:1503. [9] Meurette O, Mehlen P. Notch Signaling in the Tumor Microenvironment. Cancer Cell, 2018,34:536-548. [10] Meisel CT, Porcheri C, Mitsiadis TA. Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression. Cells,2020,9:1879. [11] Lim JS, Ibaseta A, Fischer MM, et al. Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Nature,2017,545:360-364. [12] Pagliaro L, Sorrentino C, Roti G. Targeting Notch Trafficking and Processing in Cancers. Cells,2020,9:2212. [13] Viatour P, Ehmer U, Saddic LA, et al. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med,2011,208:1963-1976. [14] Villanueva A, Alsinet C, Yanger K, et al. Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. Gastroenterology, 2012,143:1660-1669.e7. [15] Dill MT, Tornillo L, Fritzius T, et al. Constitutive Notch2 signaling induces hepatic tumors in mice. Hepatology,2013,57:1607-1619. [16] Anstee QM, Reeves HL, Kotsiliti E, et al. From NASH to HCC: current concepts and future challenges. Nat Rev Gastroenterol Hepatol,2019,16:411-428. [17] Zhu C, Ho YJ, Salomao MA, et al. Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features. J Hepatol,2021,74:613-626. [18] Rebouissou S, Franconi A, Calderaro J, et al. Genotype-phenotype correlation of CTNNB1 mutations reveals different ?-catenin activity associated with liver tumor progression. Hepatology,2016,64:2047-2061. [19] Boulter L, Govaere O, Bird TG, et al. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med,2012,18:572-579. [20] Hayward P, Kalmar T, Arias AM. Wnt/Notch signalling and information processing during development. Development,2008,135:411-424. [21] Rauff B, Malik A, Bhatti YA, et al. Notch signalling pathway in development of cholangiocarcinoma. World J Gastrointest Oncol,2020,12:957-974. |