Abstract: Objective To evaluate the correlation between ABO blood type and liver cancer from the perspective of evidence-based medicine. Methods A total of 26 case-control studies at home and abroad were included. RevMan 5.3 statistical software was used to conduct the meta analyses on the correlation between ABO blood type and liver cancer. Results There was no significant correlation between blood type and the risk of liver cancer (all P>0.05). In the subgroup analysis, blood type A was positively related to liver cancer in foreign, male and chronic liver disease populations (RR=1.16, 95% CI 1.02-1.32; RR=1.10, 95% CI 1.02-1.19; RR=1.13, 95% CI 1.04-1.22). Whereas, blood type O was negatively correlated with the occurrence of liver cancer in foreign, male and chronic liver disease populations (RR=0.85, 95% CI 0.78-0.91; RR=0.83, 95% CI 0.71-0.95; RR=0.87, 95% CI 0.80-0.96). Conclusion ABO blood type is not significantly related to the occurrence of liver cancer, but there is a relationship between ABO blood type and the occurrence of liver cancer in different populations.

Key words: Liver cancer, ABO blood type, Meta-analysis