Abstract: Objective To investigate the correlation between the level of serum glycocholic acid and adverse pregnancy outcomes in patients with intrahepatic cholestasis (ICP) during pregnancy, so as to guide early intervention in future ICP patients and promote benign pregnancy outcomes.Methods From May 2017 to April 2020, 260 patients with ICP in the hospital were selected as the research objects. The pregnancy outcomes of the patients were counted and divided into a poor pregnancy outcome group and a control group. The serum levels of glycocholic acid in the two groups were detected and the influence and predictive value of serum glycocholic acid levels on adverse pregnancy outcomes in ICP patients were analyzed.Results Among the 260 ICP patients in this study, eighty-three patients had poor pregnancy outcomes, and the incidence of adverse pregnancy outcomes was 31.92%; the serum glycocholic acid level in the adverse pregnancy outcome group was higher than that of the control group, and the difference was statistically significant (P<0.05); compared other baseline data between groups, the difference was not statistically significant (P>0.05); after single logistic regression analysis and establishment of multiple regression model, the results of multivariate analysis showed that the high expression of serum glycocholic acid was the influencing factor of the adverse pregnancy outcome of ICP patients (OR>1, P<0.05); the ROC curve was drawn and found that the AUC of serum glycocholic acid levels used to predict adverse pregnancy outcomes in ICP patients was 0.868, which had certain predictive value. And when the cut-off of serum hepatic acid was 2.670μmol/L, the best predictive value could be obtained.Conclusion Patients with ICP are at high risk of adverse pregnancy outcomes. Overexpression of serum glycocholic acid level may be involved in the occurrence of adverse pregnancy outcomes in ICP patients. Early detection of serum glycocholic acid levels can predict pregnancy outcomes, and may be of positive significance for guiding the formulation of early intervention programs and improving pregnancy outcomes.

Key words: Intrahepatic cholestasis of pregnancy, Adverse pregnancy outcome, Glycocholic acid, Total bile acid