Abstract: Objective To study the relationship between liver injury related indexes and severity of acute severe pancreatitis and neutrophil lymphocyte ratio (NLR). Methods 90 patients with severe acute pancreatitis who were treated in our hospital from October 2018 to October 2020 were included in the study, and they were divided into moderate severe acute pancreatitis (MSAP) group and severe acute pancreatitis (SAP) group according to the severity of the disease, with 45 cases in each group. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), glutamyl transpeptidase (GGT), total bilirubin (TBIL), absolute value of neutrophils, absolute value of lymphocytes and NLR were compared between the two groups. Spearman coefficient was used to analyze the correlation between the severity of severe acute pancreatitis and ALT, AST, TBIL, neutrophil absolute value, NLR. Results The levels of ALT, AST and TBIL in SAP group were significantly higher than those in MSAP group [(112.46±21.18) U/L vs (84.77±14.56) U/L, (87.46±11.57) U/L vs (67.16±9.16) U/L, (42.38±14.18) μmol/L vs (34.58±17.89) μmol/L]. The difference was significant (P<0.05). The absolute value and NLR of neutrophils in SAP group were significantly higher than those in MSAP group [(9.27±1.07)×10⁹/L vs (8.41±1.34)×10⁹/L, (8.41±2.48) vs (6.18±1.04)]. The difference was obvious (P<0.05). The severity of severe acute pancreatitis was positively correlated with ALT, AST, TBIL, neutrophil absolute value and NLR (P<0.05). Conclusion Liver injury related indicators and NLR can be used to predict the severity of severe acute pancreatitis, and there is a significant correlation between them.

Key words: severe acute pancreatitis, neutrophil lymphocyte ratio, liver injury