Abstract: Objective To explore clinical value of alanine amino transferase (ALT), preAlbumin (PAB), Albumin (Alb), alkaline phosphatase (ALP), g-glutamyl transferase (gamma-glutamyl transferase, GGT) and total bile acid (TBA) in the treatment of premature infants with different gestational ages and newborns with different birth weights. Methods The changes of ALT, PAB, Alb, ALP, GGT, TBA in 204 premature infants of different gestational ages and 206 newborns of different birth weights before and after treatment were retrospectively analyzed. We compared and analyzed the differences of various biochemical indicators in different gestational age preterm infants and different birth weight newborns. Results 1. Alb and PAB in late, middle, very preterm infants groups, and normal, low, very low birth weight newborns groups were higher than those before treatment, and the changes were the most statistically significant (P<0.05). With the recovery and improvement of liver function after treatment, ALT, GGT and TBA reduced. 2. Inter group differences: The younger the gestational age and the lighter the birth weight, the ability of liver to synthesize Alb, PAB, ALT, ALP, GGT and TBA were also different between groups of premature infants with different gestational ages and newborns with different birth weights respectively. Conclusion 1. In different gestational ages premature infants and different birth weight newborns after treatment, Alb and PAB increased significantly, and ALT and GGT decreased significantly. Alb and PAB have the most significant changes. Alb and PAB can be used as important indicators for monitoring liver function. 2. With the younger the gestational age and the lighter the weight, the liver function is easily affected, and its synthesis capacity, reserve and excretion capacity are worse.

Key words: New borns, Gestational age, Weight, Liver function, Changes, Clinical significance