Abstract: Objective To investigate the clinical characteristics and laboratory indexes of patients with alcohol-related chronic liver failure. Methods Laboratory examination results of patients with alcohol-related chronic liver failure admitted to our hospital from January 2018 to June 2021 were retrospectively analyzed. Results A total of 23 cases were enrolled. The incidence rates of jaundice, splenomegaly, ascites, hepatic encephalopathy were 100%, (73.91%), 18 cases (78.26%), and 7 cases (30.43%), respectively. The anemia type of patients in the study was mild to moderate megaloblastic anemia, with Hgb 84.52 ± 20.69 g/L and MCV102.57 ± 10.28f. Eleven cases (47.83%) with elevated alkaline phosphatase (ALP) and 4 (17.39%) with elevated gamma-glutamyl transpeptidase (GGT). The coagulation function of the patients was that prothrombin time (PT) 26.01 ± 6.83s, prothrombin activity (PTA) 35.22 ± 11.48%, international normalized ratio (INR) 2.29 ± 0.60, fibrinogen (FIB) 1.24 ± 0.56 g/L, and platelet (PLT) (57.35 ± 31.15)×10⁹/L. The increase of bilirubin was more obvious and alanine aminotransferase (ALT) were all within the normal reference value range, [total bilirubin (TBil) 165.18 ± 115.12 μmol/L, ALT 23.70 ± 11.09 U/L], and there was a trend of enzyme bile separation. Conclusion Some laboratory indexes of patients with decompensated alcohol-related chronic liver failure or compensated alcohol-related chronic liver failure are different. In patients with compensated alcohol-related chronic liver failure, the disease is more serious and the prognosis is worse.

Key words: Chronic liver failure, Alcoholic cirrhosis decompensated stage, Clinical analysis