Chinese Hepatolgy ›› 2022, Vol. 27 ›› Issue (10): 1102-1105.

• Liver Fibrosis & Cirrhosis • Previous Articles     Next Articles

An analysis on the expression of serum Nrf2 and HO-1 in patients with chronic hepatitis B-related cirrhosis and different degrees of liver injury

CHEN Ji-de1, HE Ying2, WANG Peng-sen2, LI Jian3, FENG Hua-guo3   

  1. 1. Department of Clinical Laboratory, Bishan of Chongqing Medical University Hospital, Chongqing 400030, China;
    2. Central Laboratory, Chongqing Public Health Medical Center, Chongqing 402760, China;
    3. Department of Clinical Laboratory, Jiangjin Central Hospital of Chongqing, Chongqing 402260, China
  • Received:2021-11-30 Online:2022-10-31 Published:2022-11-22

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Abstract: Objective To analyze the expression of serum nuclear factor E2 related factor 2 (Nrf2) and heme oxygenase (HO-1) in patients with chronic hepatitis B-related cirrhosis with different degrees of liver injuries. Methods 95 patients with chronic hepatitis B-related cirrhosis treated in the hospital from January 2019 to June 2020 were selected as the research subjects. The degree of liver injury (Child-Pugh grade) of all patients was evaluated at admission and divided into a mild group, a moderate group and a severe group. The patients were then investigated with a designed baseline data questionnaire. The baseline data of patients in these three groups were counted and compared, along with analyses on the association between serum Nrf2, HO-1 and the degrees of liver injuries in the patients. Results Among 95 patients with chronic hepatitis B-related cirrhosis after assessment, 29 were Child-Pugh grade A, 35 were Child-Pugh grade B, and 31 were Child-Pugh grade C. The levels of serum Nrf2 and HO-1 of patients in severe group were lower than those in moderate group and mild group, and the levels of serum Nrf2 and HO-1 of patients in moderate group were lower than those in mild group, the differences were statistically significant (P<0.05). There was no statistic significant difference in the baseline data of patients with chronic hepatitis B-related cirrhosis with different degrees of liver injuries (P>0.05). By Kendall’s tau-b correlation analysis, it was found that the degrees of liver injuries in patients with chronic hepatitis B cirrhosis was negatively correlated with the levels of serum Nrf2 and HO-1 (r<0, P<0.05). The results of multiple logistic regression analysis showed that the abnormal expression of serum Nrf2 and HO-1 may be related to the degrees of liver injuries in chronic hepatitis B cirrhosis (OR<1, P<0.05). Conclusion The abnormal low expression of serum Nrf2 and HO-1 at admission may be related to moderate and severe liver injuries in patients with chronic hepatitis B-related cirrhosis.

Key words: Chronic hepatitis B, Cirrhosis, Liver injury, Nuclear factor E2 related factor 2, Heme oxygenase