Abstract: Objective To analyze the clinical characteristics and prognosis of abnormal liver function secondary to varicella(chickenpox), so as to provide clinical decision support. Methods The clinical data of the 330 patients with varicella who were treated in our hospital from January 2010 to January 2022 were collected, and the clinical characteristics of the patients with abnormal liver function secondary to varicella were analyzed. Results Liver injury occurred in 68 patients, with an incidence rate of 20.6%. The majority of cases were in the acute stage of varicella infection without obvious clinical symptoms. The main manifestations were mild elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), in which the changes of ALT levels were more obvious. Patients with ALT <100 U/L generally did not use drug intervention, while patients with ALT>100 U/L received oral liver-protective drugs, all patients with abnormal liver function were cured and no recurrence was observed. Conclusion Although the prevalence of liver function abnormalities is common in patients with varicella, its clinical symptoms, mainly characterized by mild liver damage, are not obvious and could be cured by appropriate liver protection treatment.

Key words: Varicella, Abnormal liver function, Alanine aminotransferase, Aspartate aminotransferase, Treatment