Abstract: Objective To explore the prognosis of liver cancer patients undergoing pure caudate lobectomy, and analyze the risk factors that affect the prognosis via multivariate COX regression models.Methods 200 patients with liver cancer who underwent total caudate lobectomy in our hospital from July 2019 to July 2020 were selected for clinical and follow-up studies. The follow-up period was from July 2020 to July 2021. The clinical characteristics of all patients were collected, including age, tumor diameter, tumor TNM stage, tumor envelope, tumor location, intrahepatic metastasis, blood metastasis, portal vein cancer thrombus, liver function Child-Pugh classification, smoking, drinking, antiviral Treatment, levels of serum alpha-fetoprotein, bilirubin, aspartate aminotransferase, and the expression of epidermal growth factor receptor. Univariate analysis and multivariate COX regression were used to analyze the factors affecting the prognosis of liver cancer patients after isolated caudate lobectomy.Results Tumor diameter ≥5 cm, without tumor envelope, tumor located at the left lobe, with intrahepatic metastasis and blood metastasis, with cancer-associated potal thrombus, without antiviral therapy, alpha-fetoprotein ≥400 ng/L, bilirubin ≥34.2 μmol, aspartate aminotransferase ≥80 U/L, and aspartate aminotransferase ≥80 U/L were associated with a lower survival rate. The 1 year,follow-up results showed that the average survival time of patients was (9.50±2.31) months, and the overall survival rate of 200 patients was 54.50%; multivariate COX regression analysis showed that the presence of cancer-associated thrombus in portal vein and alpha-fetoprotein ≥400 ng/L were prognostic risk factors(P<0.05).Conclusion The 1-year survival rate of patients with liver cancer undergoing isolated caudate lobectomy is low. Among them, the presence of portal vein tumor thrombus and abnormally increased expression of alpha-fetoprotein are risk factors that affect the patients’ prognosis. It is therefore necessary to address the aboval conditions, effectively monitor and treat the patients for achieving a better prognosis.

Key words: Liver cancer, total caudate lobectomy, prognosis, influencing factors, COX regression model