Prognostic value of peripheral blood Th9 cell percentage combined with MELD score in decompensated hepatitis B cirrhosis

Abstract

Abstract: Objective To investigate the prognostic value of peripheral blood Th9 cell percentage combined with model of End-stage liver disease (MELD) score for decompensated hepatitis B cirrhosis (HBC).Methods We collected and analyzed clinical data from 107 patients with decompensated HBC admitted to the Gastroenterology Department of Hai 'an People's Hospital between May 2017 and May 2022. Based on their survival condition within 6 months after treatment, the patients were divided into a good prognosis group and a death group. The percentage of Th9 cells in peripheral blood was measured by flow cytometry, and the MELD score was evaluated for all decompensated HBC patients. General data, MELD score and percentage of Th9 cells in peripheral blood were compared between the two groups. Logistic regression analysis was conducted to identify factors influencing the prognosis of decompensated HBC. The ROC curve was used to analyze the predictive value of the combination of peripheral blood Th9 cell percentage and MELD score on the prognosis of decompensated HBC.Results Among the 107 patients with decompensated HBC, 81 survived and 26 died within 6 months after treatment. The MELD score (23.87±4.16) points and the percentage of Th9 cells in peripheral blood (3.16±0.34) % in the death group were higher than those in the survival group [(16.95±3.35) points and (1.32±0.28) % (P<0.05)]. Logistic analysis showed that both the MELD score and the percentage of Th9 cells in peripheral blood were independent risk factors for the poor prognosis of decompensated HBC (OR=3.651, 95% CI: 1.656~6.001, P<0.001; OR=3.846, 95% CI: 1.691~5.646, P<0.001). ROC analysis showed that the AUC values of the MELD score and the percentage of Th9 cells in peripheral blood to evaluate the prognosis of decompensated HBC were 0.744 and 0.779, respectively, with 95% CI from 0.651 to 0.824 and 0.688 to 0.853. When both factors are combined for prediction, the AUC value was 0.913, with a 95% CI of 0.843~0.959.Conclusion The percentage of Th9 cells in peripheral blood combined with MELD score has a high predictive value for the prognosis of decompensated HBC, providing an effective reference for clinical intervention.

Key words: Percentage of Th9 cells in peripheral blood, End-stage liver disease model score, Decompensated hepatitis B cirrhosis, Prognosis

HE Xiao-rong, TIAN Yao, GE Gui-ping. Prognostic value of peripheral blood Th9 cell percentage combined with MELD score in decompensated hepatitis B cirrhosis[J]. Chinese Hepatolgy, 2023, 28(11): 1306-1309.

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