An analysis on the latent classification and influencing factors of the characteristic symptoms in liver cirrhotic patients

Abstract

Abstract: Objective To classify the symptomatic characteristics of patients with liver cirrhosis, and to explore the demographic differences and disease characteristics in patients with different symptomatic categories. Methods A total of 220 liver cirrhotic patients in the department of infectious disease of a tertiary hospital in Shanghai from June 2020 to June 2021 were selected as the research subjects by using convenient sampling method. The general information questionnaire and memorial symptom assessment scale were used for investigating the patients. Latent classification analysis were used to classify the liver cirrhotic patients according to their symptoms. Multivariate logistic regression was used to explore the differences in demographics and disease’ characteristics of patients with different categories. Results According to symptom characteristics, patients with liver cirrhosis were divided into 2 potential categories, "symptoms high incident group" (65.45%) and "low fatigue and non-bloated group" (34.55%). Compared with the "low fatigue and non-bloated group", there were higher rates of liver tumor (28.95%/45.83%), hypoproteinemia (56.58%/70.83%), nutritional risk (39.47%/60.42%), and higher levels of ascites volume (14.47%/34.02%) and Child-Pugh grade (B+C 57.89%/69.44%), and lower ability of daily living activities (99.87/96.88) in the "symptoms high incident group" (P<0.05). Complicated with liver tumors (OR=0.526, P<0.05) and increased volume of ascites (OR=1.612, P<0.01) were the main influencing factors associated with the classifications of symptomatic characteristics in liver cirrhotic patients. Conclusion The symptomatic characteristics of liver cirrhosis are heterogeneous and can be divided into 2 latent classes. More attention should be paid to the patients complicated with liver tumor, liver function damage, hypoproteinemia, malnutrition and larger volume of ascites. The symptoms should be managed through early recognition and precise intervention.

Key words: Liver cirrhosis, Characteristic symptoms, Classification

ZHANG Shu-hua, JIANG Ping-mei, CAI Xiao-lan, CAO Zhu-jun, QIAN Zhu-ping. An analysis on the latent classification and influencing factors of the characteristic symptoms in liver cirrhotic patients[J]. Chinese Hepatolgy, 2024, 29(3): 273-277.

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