The function and prognostic value of chemokines and their receptors in hepatocellular carcinoma

Abstract

Abstract: Objective To explored the importance of chemokine and chemokine receptors (CCRs) in liver cancer by analyzing liver cancer samples in TCGA database and normal samples in GTEx database. Methods We first collected 66 CCRs, then screened the differentially expressed CCRs between the liver cancer and normal liver databases. GO functional annotation and KEGG pathway analysis was performed to explore their potential biological functions. By using univariate Cox regression and multivariate Cox regression analyses combined with Lasso regression analysis, we constructed a prediction model based on four-CCRs (CCR9、CCR7、CCR3 and ACKR2) signature. Next, a nomogram was constructed to assess the prognosis of HCC patients. Results We found that the risk score of this model was an independent prognostic factor of HCC. The correlation between the risk score and immune-cell infiltration as indicated by the four-CCRs signature might play a pivotal role in liver cancer immune microenvironment. Conclusion We constructed a prediction model which might guide personalized treatment and prognosis for liver cancer patients.

Key words: Chemokine, chemokine receptors, prognosis of liver cancer, immune cell infiltration

FENG Jie, CAI Xun-quan, PAN Qin-cong. The function and prognostic value of chemokines and their receptors in hepatocellular carcinoma[J]. Chinese Hepatolgy, 2024, 29(3): 293-299.

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