[1] Lazaridis KN, LaRusso NF. Primary Sclerosing Cholangitis[J]. N Engl J Med,2016,375:1161-1170. [2] Cadamuro M, Girardi N, Gores GJ, et al. The Emerging Role of Macrophages in Chronic Cholangiopathies Featuring Biliary Fibrosis: An Attractive Therapeutic Target for Orphan Diseases[J]. Front Med (Lausanne),2020,7:115. [3] Guicciardi ME, Trussoni CE, Krishnan A, et al. Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice[J]. J Hepatol,2018,69:676-686. [4] Gordon S, Pluddemann A. Tissue macrophages: heterogeneity and functions[J]. BMC Biol, 2017,15:53. [5] Mowat AM, Scott CL, Bain CC. Barrier-tissue macrophages: functional adaptation to environmental challenges[J]. Nat Med,2017,23:1258-1270. [6] Wynn TA, Vannella KM. Macrophages in Tissue Repair, Regeneration, and Fibrosis[J]. Immunity, 2016,44:450-462. [7] Guilliams M, Scott CL. Liver macrophages in health and disease[J]. Immunity, 2022,55:1515-1529. [8] Peiseler M, Schwabe R, Hampe J, et al. Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease-novel insights into cellular communication circuits[J]. J Hepatol,2022,77:1136-1160. [9] Schuster S, Cabrera D, Arrese M, et al. Triggering and resolution of inflammation in NASH[J]. Nat Rev Gastroenterol Hepatol, 2018,15:349-364. [10] Peiseler M, Araujo David B, Zindel J, et al. Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver. Science,2023,381:eabq5202. [11] Mihm S. Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver[J]. Int J Mol Sci,2018,19. [12] Mitchell C, Couton D, Couty JP, et al. Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice[J]. Am J Pathol,2009,174:1766-1775. [13] Seki E, de Minicis S, Inokuchi S, et al. CCR2 promotes hepatic fibrosis in mice. Hepatology, 2009,50:185-197. [14] Cai X, Li Z, Zhang Q, et al. CXCL6-EGFR-induced Kupffer cells secrete TGF-beta1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis[J]. J Cell Mol Med,2018,22:5050-5061. [15] Lefere S, Degroote H, Van Vlierberghe H, et al. Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers[J]. J Hepatol,2019,71:631-633. [16] Guilliams M, Bonnardel J, Haest B, et al. Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches[J]. Cell,2022,185:379-396 e338. [17] De Muynck K, Heyerick L, De Ponti FF, et al. Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis[J]. Hepatology,2024,79:269-288. [18] Bonnardel J, T'Jonck W, Gaublomme D, et al. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche[J]. Immunity,2019,51:638-654 e639. [19] Ginhoux F, Bleriot C, Lecuit M. Dying for a Cause: Regulated Necrosis of Tissue-Resident Macrophages upon Infection[J]. Trends Immunol,2017,38:693-695. [20] Sierro F, Evrard M, Rizzetto S, et al. A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment[J]. Immunity,2017,47:374-388 e376. [21] Remmerie A, Martens L, Thone T, et al. Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver[J]. Immunity,2020,53:641-657 e614. [22] Guillot A, Winkler M, Silva Afonso M, et al. Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression[J]. Hepatology,2023,78:150-166. [23] Song Z, Chen W, Athavale D, et al. Osteopontin Takes Center Stage in Chronic Liver Disease[J]. Hepatology,2021,73:1594-1608. [24] Han H, Ge X, Komakula SSB, et al. Macrophage-derived Osteopontin (SPP1) Protects From Nonalcoholic Steatohepatitis[J]. Gastroenterology,2023,165:201-217. [25] Honda M, Kimura C, Uede T, et al. Neutralizing antibody against osteopontin attenuates non-alcoholic steatohepatitis in mice[J]. J Cell Commun Signal,2020,14:223-232. |