[1] Siegel R L, Miller K D, Fuchs H E, et al. Cancer statistics, 2021[J]. CA Cancer J Clin, 2021, 71(1):7-33.
[2] Wang Y C, Wang Z J, Zhang C, et al. Cell reprogramming in liver with potential clinical correlations[J]. J Dig Dis, 2022, 23(1):13-21.
[3] Lee J, Choi J, Kang S, et al. Hepatogenic potential and liver regeneration effect of human liver-derived mesenchymal-like stem cells[J]. Cells, 2020, 9(6):1521.
[4] Ullah I, Shin Y, Kim Y, et al. Effect of sex-specific differences on function of induced hepatocyte-like cells generated from male and female mouse embryonic fibroblasts[J]. Stem Cell Res Ther, 2021, 12(1):79.
[5] Hagiwara R, Oki Y, Matsumaru T, et al. Generation of metabolically functional hepatocyte-like cells from dedifferentiated fat cells by Foxa2, Hnf4a and Sall1 transductions[J]. Genes Cell, 2020, 25(12):811-824.
[6] Liang R, Wang Z, Kong X, et al. Differentiation of human parthenogenetic embryonic stem cells into functional hepatocyte-like cells[J]. Organogenesis, 2020, 16(4):137-148.
[7] Nitta S, Kusakari Y, Yamada Y, et al. Conversion of mesenchymal stem cells into a canine hepatocyte-like cells by Foxa1 and Hnf4a[J]. Regen Ther, 2020, 14:165-176.
[8] Bolleyn J, Rombaut M, Nair N, et al. Genetic and epigenetic modification of rat liver progenitor cells via HNF4α transduction and 5' azacytidine treatment: an integrated miRNA and mRNA expression profile analysis[J]. Genes (Basel), 2020, 11(5):486.
[9] Schonfeld M, Averilla J, Gunewardena S, et al. Male-specific activation of Lysine Demethylases 5B and 5C mediates alcohol-Induced liver injury and hepatocyte dedifferentiation[J]. Hepatol Commun, 2022, 6(6):1373-1391.
[10] Gárate-Rascón M, Recalde M, Jimenez M, et al. Splicing factor SLU7 prevents oxidative stress-mediated hepatocyte nuclear factor 4α degradation, preserving hepatic differentiation and protecting from liver damage[J]. Hepatology, 2021, 74(5):2791-2807.
[11] Cheng C C, Yang W Y, Hsiao M C, et al. Transcriptomically revealed Oligo-Fucoidan enhances the immune system and protects hepatocytes via the ASGPR/STAT3/HNF4A axis[J]. Biomolecules, 2020, 10(6):898.
[12] Wu D, Wang Y, Yang G, et al. A novel mitochondrial amidoxime reducing component 2 is a favorable indicator of cancer and suppresses the progression of hepatocellular carcinoma by regulating the expression of p27[J]. Oncogene, 2020, 39(38):6099-6112.
[13] Ko H L, Zhuo Z, Ren EC. HNF4α combinatorial isoform heterodimers activate distinct gene targets that differ from their corresponding homodimers[J]. Cell Rep, 2019, 26(10):2549-2557.
[14] Xue T C, Jia Q A, Bu Y, et al. CXCR7 correlates with the differentiation of hepatocellular carcinoma and suppresses HNF4α expression through the ERK pathway[J]. Oncol Rep, 2014, 32(6):2387-2396.
[15] Wu J, Lu M, Li Y, et al. Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells[J]. Oncogene, 2016, 35(42):5468-5479.
[16] Zheng B N, Ding C H, Chen S J, et al. Targeting PRMT5 activity inhibits the malignancy of hepatocellular carcinoma by promoting the transcription of HNF4α[J]. Theranostics, 2019, 9(9):2606-2617.
[17] 肖志刚, 郑丽, 王梓瀛, 等. 小鼠第 13.5 天胚肝细胞诱导 HepG2 细胞分化的作用机制[J]. 中国比较医学杂志, 2022(4), 32:47-53.
[18] Li Y, Liu D, Zong Y, et al. Developmental stage-specific hepatocytes induce maturation of HepG2 cells by rebuilding the regulatory circuit[J]. Mol Med, 2015, 21(1):285-295.
[19] Li Y, Zong Y, Xiao Z, et al. Developmental stage-specific embryonic induction of HepG2 cell differentiation[J]. Dig Dis Sci, 2016, 61(4):1098-1106.
[20] Haque E, Teeli A S, Winiarczyk D, et al. HNF1A POU domain mutations found in Japanese liver cancer patients cause downregulation of HNF4A promoter activity with possible disruption in transcription networks[J]. Genes (Basel), 2022, 13(3):413.
[21] Španinger E, Potočnik U, Bren U. Molecular dynamics simulations predict that rSNP located in the HNF-1α gene promotor region linked with MODY3 and hepatocellular carcinoma promotes stronger binding of the HNF-4α transcription factor[J]. Biomolecules, 2020, 10(12):1700.
[22] Cheng Z, He Z, Cai Y, et al. Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors[J]. Cell Res, 2019, 29(2):124-135.
[23] Prabhakar B, Lee S, Bochanis A, et al. lnc-RHL, a novel long non-coding RNA required for the differentiation of hepatocytes from human bipotent progenitor cells[J]. Cell Prolif, 2021, 54(2):e12978.
[24] Rodríguez-Aguilera J R, Ecsedi S, Goldsmith C, et al. Genome-wide 5-hydroxymethylcytosine (5hmC) emerges at early stage of in vitro differentiation of a putative hepatocyte progenitor[J]. Sci Rep, 2020, 10(1):7822.
[25] Zhong Y, Qi H, Li X, et al. Tumor supernatant derived from hepatocellular carcinoma cells treated with vincristine sulfate have therapeutic activity[J]. Eur J Pharm Sci, 2020, 155:105557.
[26] Russell J O, Ko S, Monga S P, et al. Notch inhibition promotes differentiation of liver progenitor cells into hepatocytes via sox9b repression in zebrafish[J]. Stem Cells Int, 2019, 2019:8451282.
[27] Xu J, Zheng Z, Du X, et al. A cytokine screen using CRISPR-Cas9 knock-in reporter pig iPS cells reveals that activin a regulates NANOG[J]. Stem Cell Res Ther, 2020, 11(1):67.
[28] Li Y, Hu J, Guo D, et al. LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway[J]. Cancer Gene Ther, 2022, 29(10):1373-1383.
[29] Alemohammad H, Motafakkerazad R, Asadzadeh Z, et al. siRNA-mediated silencing of Nanog reduces stemness properties and increases the sensitivity of HepG2 cells to cisplatin[J]. Gene, 2022, 821:146333.
[30] Wang L, Ma R, Jia G, et al. Effect of BMP-Wnt-Nodal signal on stem cell differentiation[J]. Zygote, 2022, 30(1):138-143.
[31] Pan T, Wang N, Zhang J, et al. Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy[J]. Stem Cell Res Ther, 2022, 13(1):159.
[32] Dubois V, Staels B, Lefebvre P, et al. Control of cell identity by the nuclear receptor HNF4 in organ pathophysiology[J]. Cells, 2020, 9(10):2185.
[33] Song J, Zhou H, Gu D, et al. Hepatocellular carcinoma differentiation: research progress in mechanism and treatment[J]. Front Oncol, 2021, 11:790358. |
