Correlation analysis of enhanced MRI multimodal parameters and liver function grading in patients with primary liver cancer

Abstract

Abstract: Objective To analyze the correlation between multimodal parameters of enhanced magnetic resonance imaging (MRI) and liver function grading in patients with primary liver cancer. Methods Seventy patients with primary liver cancer treated at the hospital from September 2020 to September 2023 were enrolled, and were divided into grade A (n=21), grade B (n=36) and grade C (n=13) according to Child-Pugh classification. Spearman rank correlation analysis was used to compare the consistency of enhanced MRI with surgical pathological grade and the correlation of enhanced MRI multimodal parameters with liver function grade in patients with primary liver cancer. Results Consistency analysis showed that the accuracy, sensitivity, specificity, positive predictive value, negative predictive value and Kappa value were 91.43%, 90.48%, 92.86%, 95.00%, 92.86%, 0.824, respectively. The T1, D* and f values [(503.49±40.32) ms, (61.35±5.89) ×10^-3 mm²/s, (28.65±3.27) %] of patients with liver function grade A were lower than those of patients with liver function grade B [(545.67±45.39) ms, (65.87±6.36) ×10^-3 mm²/ s, (33.26±3.82) %]. T2, ADC and D values [(73.56±6.82) ms, (1.67±0.32) ×10^-3 mm²/s, (1.47±0.19) ×10^-3 mm²/s] were higher than those with grade B liver function [(65.43±5.89) ms, (1.41±0.26) ×10^-3 mm²/s, (1.2 8±0.16) ×10^-3 mm²/s]. T1, D* and f values of patients with liver function grade B were lower than those of patients with grade C liver function [(575.52±56.31) ms, (71.33±6.52) ×10^-3 mm²/s, (36.13±4.36) %]. T2, ADC and D values were significantly higher than those with grade C liver function [(61.26±5.37) ms, (1.24±0.19) ×10^-3 mm²/s, (1.06±0.13) ×10^-3 mm²/s] (P<0.05). Correlation analysis showed that T1, D* and f values were positively correlated with liver function grade in patients with primary liver cancer (r=0.535, 0.432, 0.519, P<0.05), while T2, ADC and D values were negatively correlated with liver function grade (r=-0.426, -0.597, -0.524, P<0.05). Conclusion Enhanced magnetic resonance imaging (MRI) multimodal parameters can effectively modify the degree of liver function in patients with primary liver cancer, and can be combined with the above results in clinical diagnosis and treatment plan.

Key words: Multimodal parameters of enhanced magnetic resonance imaging, Primary liver cancer, Liver function classification, Correlation

CHEN Yan-xia, A Ni, XU Xuan, BAI Rong, LIU Xiao-zhi. Correlation analysis of enhanced MRI multimodal parameters and liver function grading in patients with primary liver cancer[J]. Chinese Hepatolgy, 2024, 29(6): 667-670.

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