Chinese Hepatolgy ›› 2024, Vol. 29 ›› Issue (6): 714-718.

• Other Liver Diseases • Previous Articles     Next Articles

Effects of ultrasound-guided lauromacrogol sclerotherapy on liver function and levels of Cor, AD,and NE in patients with hepatic cysts

HAO Dong1, WANG Chen-xi2, ZHANG Kun-jie3   

  1. 1. Second Department of Surgery, Tanghe County Traditional Chinese Medicine Hospital, Henan 473400, China;
    2. Fourth Department of General Surgery, Nanyang Medical College First Affiliated Hospital, Henan 473000, China;
    3. First Department of General Surgery, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
  • Received:2024-02-01 Online:2024-06-30 Published:2024-08-28

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Abstract: Objective To evaluate the effects of ultrasound-guided lauromacrogol sclerotherapy on liver function and stress hormone levels in patients with hepatic cysts. Methods Sixty-two patients with hepatic cysts admitted to our hospital from January 2020 to March 2023 were randomly assigned to either the observation group or the control group, with 31 patients in each group. The control group received anhydrous ethanol injections under ultrasound guidance, while the observation group received lauromacrogol injections under ultrasound guidance. Clinical efficacy was evaluated in both groups. Liver function was assessed and compared between the groups before and one week after the procedure. Stress indices and routine blood parameters [platelet count (PLT), white blood cell count (WBC), hemoglobin (Hb)] were measured and compared before and one day after the procedure. Complications were also recorded in both groups. Results There was no significant difference in the total effective rate between the two groups (93.55% vs 90.32%, P>0.05). One week post-operation, alanine aminotransferase(ALT) and aspartate aminotransferase(AST) levels in the control group were significantly elevated (P<0.05), and were notably higher than those in the observation group [(47.36±11.27) U/L vs. (62.41±10.35) U/L and (38.06±5.62) U/L vs. (72.85±21.96) U/L, respectively] (P<0.05). One day post-operation, stress indices in both groups increased significantly (P<0.05), but were lower in the observation group [(0.25±0.06) ng/mL vs. (0.32±0.05) ng/mL, (277.16±24.79) ng/mL vs. (317.42±30.15) ng/mL, (60.14±5.49) pg/mL vs. (66.87±7.05) pg/mL] (P<0.05). PLT and Hb levels showed no significant changes compared to pre-treatment values in both groups (P>0.05), while WBC cout in the control group significantly increased (P<0.05) and was higher than in the observation group [(37.32±6.55) ×109/L vs. (41.38±8.07) ×109/L](P<0.05). The incidence of adverse reactions was lower in the observation group (P<0.05). Conclusion Lauromacrogol is effective in the treatment of hepatic cysts, demonstrating minimal impact on liver function, stress response, and inflammatory response, while also reducing the incidence of complications. These findings highlight its clinical significance.

Key words: Hepatic cyst, Ultrasonic guidance, Lauromacrogol, Sclerotherapy, stress