Chinese Hepatolgy ›› 2024, Vol. 29 ›› Issue (10): 1217-1220.

• Liver Cancer • Previous Articles     Next Articles

Value of magnetic resonance imaging multimodal parameters combined with contrast-enhanced ultrasound parameters in the diagnosis of focal nodular hyperplasia of liver without scar

WU Ai-qiang1, YOU Ren-fang2, YANG Qian3, YU Jin1, YU Hai-xia1   

  1. 1. Department of Health Medicine, the 910th Hospital of People's Liberation Army Joint Logistic Support Force, Quanzhou 362000, China;
    2. Department of Anesthesiology, the 910th Hospital of People's Liberation Army Joint Logistic Support Force, Quanzhou 362000, China;
    3. Department of Imaging, the Second People's Hospital of Guizhou Province (Affiliated Hospital of Zunyi Medical University), Guiyang 550081, China
  • Received:2024-04-14 Online:2024-10-31 Published:2024-12-02

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Abstract: Objective To evaluate the value of magnetic resonance imaging (MRI) multimodal parameters combined with contrast-enhanced ultrasound (CEUS) parameters in the diagnosis of focal nodular hyperplasia of the liver without scar. Methods The clinical data of 56 patients with non-scar focal nodular hyperplasia of liver admitted to the hospital from January 2016 to July 2023 were retrospectively analyzed as the study group, and the clinical data of 67 patients with hepatocellular carcinoma without cirrhosis were retrospectively analyzed as the control group. All subjects underwent the examinations including intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), MRI, contrast-enhanced ultrasound (CEUS), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). By comparing the general data, MRI multimodal parameters and CEUS parameters of the two groups , we analyzed the factors related to the occurrence of cicatricial focal nodular hyperplasia of the liver, as well as the diagnostic value of the combination of parameters for the occurrence of focal nodular hyperplasia in the liver without scar was analyzed. Results There was no difference in signal enhancement rate (SER) and proportion of fast diffusion components (f) between the two groups (P>0.05). The values of maximum slope of decrease (MSD), maximum slope of increase (MSI), rapid apparent diffusion coefficient (D*), apparent diffusion coefficient (ADC), proportion of rapid diffusion components (f) and slow apparent diffusion coefficient (D) in the study group were higher than control group (P<0.05). The study group with peak intensity (PI) was lower than control group (P<0.05), and the study group with peak time (TTP) and start enhancement time (AT) were higher than control group (P<0.05). Logistic regression analysis showed that MSD (OR=3.943, 95%CI: 1.733~8.970), TTP (OR=4.162, 95%CI: 1.830~9.468), AT (OR=4.536, 95%CI: 1.994~10.318) and ADC (OR=3.333, 95%CI: 1.465~7.583) were associated with the occurrence of focal nodular hyperplasia of liver without scar (P<0.05). The area under the curve (AUC) values of MSD, TTP, AT, ADC and the combined diagnosis of scar-free focal nodular hyperplasia of liver were 0.815, 0.804, 0.822, 0.793 and 0.901, respectively (P<0.05). And the combined AUC was higher (P<0.05). Conclusion MSD, TTP, AT and ADC are of great value in the diagnosis of cicatar-free focal nodular hyperplasia of the liver, and the combined value of the four is higher.

Key words: Magnetic resonance imaging, Multimodal parameters, Contrast-enhanced ultrasound parameters, Hepatic focal nodular hyperplasia without scar, Diagnostic value