Clinical characteristics of 60 cases of yellow granulomatous cholecystitis and imaging manifestation differentiation from gallbladder cancer

Abstract

Abstract: Objective To analyze the clinical features of 25 cases of yellow granulomatous cholecystitis and differentiate their imaging manifestations from those of gallbladder cancer. Methods Sixty patients with surgically and pathological diagnoses of yellow granulomatous cholecystitis and gallbladder cancer, admitted to our hospital between May 2019 and May 2023, were divided into the cholecystitis and gallbladder cancer groups. We compared the clinical features and imaging manifestations of the two groups and analyzed the diagnostic value of imaging manifestations in distinguishing yellow granulomatous cholecystitis from gallbladder cancer using the receiver operating characteristic (ROC) curve. Results The decrease in body mass index(BMI) in the cholecystitis group was (14.1 ± 0.4) kg/m², and the proportion of patients with decreased appetite was 36.0%, both lower than those in the gallbladder cancer group, which had values of 16.2 ± 0.1 kg/m² and 80.0%, respectivey (P<0.05). The incidence of gallbladder stones, diffuse thickening of the gallbladder wall, continuous integrity of the mucosal line, and transient enhancement in the arterial phase of adjacent hepatic parenchyma was 72.0%, 60.0%, 80.0%, and 76.0%, respectively, in the Cholecystitis group, all higher than in the gallbladder cancer group [28.6%, 28.6%, 34.3%, and 42.9%, respectively; P<0.05]. ROC curve analysis indicated that gallbladder stones, diffuse thickening of the gallbladder wall, continuous integrity of the mucosal line, and transient enhancement in the arterial phase of adjacent liver parenchyma are valuable for differentiating yellow granulomatous cholecystitis from gallbladder cancer. Conclusion Yellow granulomatous cholecystitis often clinically manifests as decreased body weight, appetite, gallstones, diffuse thickening of the gallbladder wall, continuous integrity of the mucosal lining, and transient enhancement in the arterial stage adjacent to liver parenchyma which is highly valuable for differentiating yellow granulomatous cholecystitis from gallbladder cancer.

Key words: Yellow granulomatous cholecystitis, Clinical features, Gallbladder cancer, Imaging

WANG Bin, HUA Xing, ZHOU Chen. Clinical characteristics of 60 cases of yellow granulomatous cholecystitis and imaging manifestation differentiation from gallbladder cancer[J]. Chinese Hepatolgy, 2024, 29(10): 1269-1273.

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