Abstract: Objective To investigate the application value of multi-slice spiral CT (MSCT) in the diagnosis of portal hypertension in liver cirrhosis. Methods A total of 100 cirrhotic patients with portal hypertension who were treated in our hospital between July 2020 and July 2023 were selected as the observation group. Ninety-five healthy people who underwent physical examination in our hospital during the same period of time were selected as the control group. MSCT examination was performed in all patients. The related indexes of portal vein system [main portal vein (MPV), splenic vein (SPV), left branch of intrahepatic portal vein (IHLPV), right branch of intrahepatic portal vein (IHRPV)] of the two groups, and the related indexes of portal vein system of patients with different liver function grades were compared. The values of using portovenous system-related indicators in the diagnosis of portal hypertension in cirrhotic patients were analyzed by receiver operating characteristic (ROC) curve consistency method. Results The MPV, SPV, IHLPV and IHRPV in the observation group were [(18.42±4.21) mm, (14.53±3.61) mm, (13.52±3.27) mm, (13.87±3.52) mm], respectively, which were higher than those of [(11.37±2.70) mm, (9.23±1.88) mm, (9.16±1.62) mm, (9.25±1.62) mm] in the control group (P<0.05); The diameters of MPV, SPV, IHLPV and IHRPV in grade C patients were [(21.15±3.83) mm, (16.49±3.05) mm, (16.07±3.12) mm, (16.11±3.25) mm], respectively, which were higher than those of [(18.19±3.02) mm, (15) .01±2.54] mm, (14.58±2.95) mm, (14.57±3.03) mm] in grade B patients. These parameters in patients with liver function grade B were higher than those of [(16.57±2.31) mm, (13.37±2.03) mm, (13.15±2.55) mm, (13.16±2.74) mm] in patients with liver function grade A (P<0.05). With MPV≥13.68 mm, SPV≥11.32 mm, IHLPV≥11.75mm and IHRPV≥10.9 mm as cut-off points, the areas under the curve (AUC) of MPV, SPV, IHLPV and IHRPV for the diagnosis of portal hypertension in cirrhosis was 0.801 (95%CI: 0.707~0.894), 0.702 (95%CI: 0.587~0.817), 0.806 (95%CI: 0.705~0.907), and 0.813 (95%CI: 0.720~0.906), with all P<0.05; By consistency analysis it was confirmed that the accuracy of MSCT measurement of portal vein system related indicators in the diagnosis of portal hypertension in cirrhosis was 96.00%, with a sensitivity of 96.74%, specificity of 87.50%, positive predictive value of 98.89%, negative predictive value of 70.00%, Kappa value =0.756. Conclusion MSCT measurement of portal vein system-related indicators for the diagnosis of cirrhosis portal hypertension has high accuracy, sensitivity and specificity, which is conducive not only to reducing the occurrence of missed diagnosis and misdiagnosis, but also to dynamically monitoring of patients' conditions, The detection operation method is non-invasive and convenient, which can provide reliable basis for clinical diagnosis and treatment, with high promotion value.

Key words: Multislice spiral CT, Portal vein system, Liver cirrhosis, Portal hypertension, Liver function