Association of blood metabolites with primary sclerosing cholangitis risk: a two-sample Mendelian randomized study

Abstract

Abstract: Objective To investigate the association between blood metabolite levels and the risk of primary sclerosing cholangitis(PSC) using Mendelian randomization. Methods Genome-wide association study (GWAS) data for PSC and blood metabolites were obtained. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables, and two-sample Mendelian randomization (MR) analyses were conducted using inverse variance weighting, the weighted median method, and MR-Egger regression. Results Higher levels of mannitol (P=0.049), urea (P=0.035), linoleate (18:2n6) (P=0.049), caffeine (P=0.039), and leucine (P=0.019) were positively associated with an increased risk of PSC. In contrast, elevated levels of L-carnitine (P=0.049), vitamin C (P=0.017), pantothenate (P=0.005), palmitate (16:0) (P=0.030), and creatinine (P=0.043) were negatively associated PSC risk. Conclusion Eleven metabolites may have causal associations with chronic kidney disease, offering potential insights for understanding its pathogenesis and aiding in early screening and therapeutic strategies.

Key words: Blood metabolites, Mendelian randomization, Correlation study, Primary sclerosing cholangitis

WANG Zeng-xiu, WU Wei-feng. Association of blood metabolites with primary sclerosing cholangitis risk: a two-sample Mendelian randomized study[J]. Chinese Hepatolgy, 2024, 29(11): 1401-1404.

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