An observation study on the therapeutic efficacy of ultrasound-guided microwave ablation combined with camrelizumab for advanced primary liver cancer

Abstract

Abstract: Objective To observe the therapeutic efficacy of ultrasound-guided microwave ablation combined with camrelizumab for advanced primary liver cancer (PLC).Methods A total of 97 patients with middle and late stages of PLC were selected from March 2020 to February 2022.They were divided into a control group (48 cases) and an observation group (49 cases) according to different treatment methods. The control group received ultrasound-guided microwave ablation, and the observation group received additional carrilizumab treatment. The immune function, tumor marker levels [abnormal prothrombin (DCP), alpha-fetoprotein heteroplasmic (AFP-L3), carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA)], clinical efficacy [disease control rate (DCR) and Objective response rate (ORR)] and adverse reactions were compared between the two groups. The overall survival of the two groups was recorded during 1-year follow-up.Results After treatment, serum immunoglobulin A (IgA), IgM and IgG levels in the observation group were (2.75±0.52) g/L, (18.74±3.24) g/L and (48.79±6.51) g/L, respectively, which were significantly higher than those of [(1.31±0.24) g/L, (8.45±1.62) g/L and (26.79±4.20) g/L in the control group (P<0.05). The levels of AFP-L3, DCP, CA199 and CEA in the observation group after treatment were (177.81±36.47) ng/mL, (26.15±3.24) mAU/mL, (50.28±4.03) ng/L, and (8.79±1.65) ng/mL, respectively, which was lower than those of [(287.39±56.21) ng/mL, (35.27±4.82) mAU/mL, (72.34±5.16) ng/L, and (26.37±3.20) ng/mL in the control group (P<0.05). The observation group demonstrated significantly higher DCR and ORR when compared to the control group (P<0.05). At 1-year follow-up, the observation group exhibited a survival rate of 79.17% (38/48), while the control group had a survival rate of 55.32% (26/47).Conclusion Ultrasound-guided microwave ablation combined with carrellizumab may improve immune function and reduce the levels of serum tumor markers in advanced PLC patients, and significantly improve their survival rate.

Key words: Primary liver cancer, Microwave ablation, Carrilizumab, Clinical effect, Prognosis

SHU Jia-ju, YE Xi-rong. An observation study on the therapeutic efficacy of ultrasound-guided microwave ablation combined with camrelizumab for advanced primary liver cancer[J]. Chinese Hepatolgy, 2024, 29(12): 1493-1497.

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