Abstract: Objective To explore the current situation of kinesiophobia in patients with postoperative spinal metastases of liver cancer, analyze the potential influencing factors of kinesiophobia, and provide a research basis for the prevention and treatment of kinesiophobia in patients with postoperative spinal metastases of liver cancer. Methods Sixty-nine postoperative patients with spinal metastases of liver cancer treated in the Department of Orthopedics, Third Affiliated Hospital of Naval Medical University from November 2021 to January 2023 were selected, and the General Information Questionnaire, Tampa Scale for Kinetophobia (TSK), Visual Analogue Scale for Pain (VAS), General Self-efficacy Scale (MCSQ) and Family Care Index Questionnaire (APGAR) were applied to collect relative data. Subsequently, single factor statistical methods were used to analyze whether general information and correlated factors differed between the kinesiophobia and non- kinesiophobia groups. We further use multifactorial logistic regression analysis on variables that have statistical significance in univariate analysis to investigate the factors influencing the development of kinesiophobia in patients with postoperative spinal metastases of liver cancer. Results The incidence of postoperative kinesiophobia in patients with spinal metastases was 39.13%. Univariate analysis showed a positive association between the occurrence of kinesiophobia and longer preoperative pain duration, higher postoperative pain level, lower self-efficacy, and poor family care among patients. After correction of confounding factors by multifactorial logistic regression analysis, longer preoperative pain duration and higher postoperative pain level were considered as risk factors for the occurrence of postoperative kinesiophobia in patients with spinal metastases of liver cancer, while high self-efficacy was a protective factor (P<0.05). Conclusion Higher incidence of kinesiophobia in patients with spinal metastases of liver cancer is associated with longer preoperative pain duration, higher postoperative pain level, and lower self-efficacy. Early detection and intervention of the above factors should be emphasized in clinical practice, which is of great clinical significance to prevent the occurrence of postoperative kinesiophobia and improve the prognosis of these patients.

Key words: Liver cancer, Spinal metastases, Kinesiophobia, Influencing factor