EGF rs4444903 gene polymorphism is associated with the risk of HCV infection-related hepatocellular carcinoma: a Meta-analysis

Abstract

Abstract: Objective To investigate the association between EGF polymorphisms on rs4444903 locus and the risk of HCV infection-related hepatocellular carcinoma (HCC). Methods A computer-based search was performed on all case-control studies in the databases of PubMed, CNKI, Wan Fang Date, Springer-Verlag, Cochrane and Embase to identify the association of EGF rs4444903 polymorphisms with the risk of HCV infection-related HCC. Meta-analysis was performed by applying Stata 17.0 software, and the OR and 95% CI were calculated. A sensitivity analysis was performed, and the publication bias was evaluated. Results A total of five case-control studies were included in this meta-analysis study. It was shown that EGF rs4444903 gene polymorphisms were significantly associated with the risk of HCV infection-related HCC: 1) allelic model G vs A: (OR=1.48, 95% CI: 1.22~1.80, P=0.001); 2) pure model GG vs AA: (OR=2.54, 95% CI: 1.65~3.91, P=0.001); 3) recessive model GG vs GA+AA: (OR=1.76, 95% CI: 1.16~2.66, P=0.01). Conclusion EGF rs4444903 gene polymorphism was significantly associated with the risk of HCV infection-related HCC.

Key words: EGF, Polymorphism, Hepatitis C virus, Hepatocellular carcinoma, Meta-analysis

WANG Hui, BIAN Na-na, FENG Gong, ZHANG Fen-na, ZHANG Xin-yi, WANG Zi-yi, SUN Rong-rong, HE Na. EGF rs4444903 gene polymorphism is associated with the risk of HCV infection-related hepatocellular carcinoma: a Meta-analysis[J]. Chinese Hepatolgy, 2025, 30(5): 624-629.

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