Chinese Hepatolgy ›› 2025, Vol. 30 ›› Issue (10): 1354-1359.

• Liver Cancer • Previous Articles     Next Articles

Relationship between DCE-MRI quantitative perfusion parameters and MRI image texture parameters and TACE efficacy in primary liver cancer

ZHANG Hai-jun1, LUO Ke-chun1, BAO Jun-jun2   

  1. 1. Department of Radiology,Hai′an Traditional Chinese Medicine,Nantong 226600,China;
    2. Department of Thoracic Surgery,Hai′an Traditional Chinese Medicine,Nantong 226600,China
  • Received:2024-08-20 Online:2025-10-31 Published:2025-12-16
  • Contact: LUO Ke-chun

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Abstract: Objective To analyze the relationship between dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) quantitative perfusion parameters and MRI image texture parameters and the therapeutic effect of transcatheter arterial chemoembolization (TACE) for primary liver cancer. Methods The medical records of 101 patients with primary liver cancer treated with TACE from March 2022 to May 2023 were retrospectively analyzed. All patients received TACE treatment and were divided into ineffective group [disease progression (PD) + stable disease (SD)] and effective group [partial response (PR) + total response (CR)] according to the treatment effect. The DCE-MRI quantitative perfusion parameters, MRI image texture parameters and clinical data of the two groups were compared to analyze the influencing factors of the ineffective TACE treatment for primary liver cancer, and analyze the predictive value of DCE-MRI quantitative perfusion parameters combined with MRI image texture parameters for the ineffective TACE treatment for primary liver cancer. Results After a three-month treatment, among 101 patients with primary liver cancer, there were 2 cases of CRs, 54 cases of PRs, 32 cases of SDs, 13 cases of PDs, 56 cases of effective group, and 45 cases of ineffective group. The interstitial plasma rate constant (Kep) and volume transfer constant (Ktrans) of the ineffective group were lower than those of the effective group (P<0.05), and there was no difference in extracellular space volume fraction (Ve) and plasma volume fraction (Vp) between the two groups (P>0.05). The standard deviation of invalid value was higher than that of effective group (P<0.05), and the inertness of invalid group was lower than that of effective group (P<0.05). There were no significant differences in entropy, skewness, evenness and mean value in 2 groups (P>0.05). The carbohydrate antigen 199 and tumor diameterin the ineffective group were higher than effective group (P<0.05). Ktrans, Kep, inertia, standard deviation and tumor diameter were the influential factors of TACE treatment for primary liver cancer (P<0.05). The area under the curve (AUC) values of Ktrans, Kep, standard deviation, inertia and the four combined predicted the failure of TACE treatment for primary liver cancer were 0.803, 0.795, 0.824, 0.816, 0.903 (P<0.05), respectively. The combined AUC value of the four indexes was higher than predicted by the single index (P<0.05). Conclusion Ktrans, Kep, inertia and standard deviation have important value in predicting TACE efficacy of primary liver cancer, and the joint model of the four indicators has higher predictive value.

Key words: Dynamic contrast enhanced magnetic resonance imaging, Perfusion parameters, Magnetic resonance imaging, Texture parameters, Primary liver cancer, Transcatheter arterial chemoembolization, Curative effect, Predictive value