Chinese Hepatolgy ›› 2025, Vol. 30 ›› Issue (10): 1379-1383.

• Viral Hepatitis • Previous Articles     Next Articles

Predictive value of interferon γ inducible protein 10 combined with HBV pgRNA for pregnancy outcomes in pregnant women with HBV infection

YU Hong-yun1, HUANG Yan1, DING Jian-fen1, CAI Liang-liang2, SHU Chang-zhen1   

  1. 1. Department of Obstetrics and Gynecology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou 215101, China;
    2. Department of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214014, China
  • Received:2024-10-10 Online:2025-10-31 Published:2025-12-16
  • Contact: SHU Chang-zhen, Email:15862486627@163.com

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Abstract: Objective To investigate the predictive value of interferon Y-inducible protein 10 (IP-10) combined with hepatitis B virus (HBV) genomic RNA (pgRNA) in pregnancy outcomes. Methods A total of 102 pregnant women with HBV infection admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from March 2020 to December 2023 were selected. IP-10 levels and HBV pgRNA were detected after admission. All pregnant women were followed up from after discharge until all of them gave birth, and they were divided into poor pregnancy outcome group and good pregnancy outcome group according to pregnancy outcomes. The basic data of patients were compared, and the factors affecting the adverse pregnancy outcome were analyzed. Results Among the 102 pregnant women, 23 had adverse pregnancy outcomes (22.55%), including 6 premature births, 5 cases of abnormal amniotic fluid volume, 5 cases of postpartum hemorrhage ≥500 mL, 2 cases of placental abruption, 2 cases of low body weight infant, 2 cases of macrosomia, and 1 case of growth restriction. In the adverse pregnancy outcome group, aspartate aminotransferase (AST) (22.83±3.86) U/L, alanine aminotransferase (ALT) (17.23±2.54) U/L, HBV pgRNA (5.26±1.14) log 10 copies/mL and IP-10 (68.26±6.85) pg/mL were higher than those in the good pregnancy outcome group (19.74±3.18) U/L, (14.93±2.21) U/L and (4.31±1.04) log 10 copies/mL, (62.14±5.74) pg/mL (all P<0.05). Logistic analysis showed that the levels of AST [OR=1.349 (95%CI: 1.132~1.606)], ALT [OR=1.583 (95%CI: 1.232~2.035)], HBV pgRNA [OR=2.518 (95%CI: 1.449~4.375)] and IP-10 [OR=1.185 (95%CI: 1.078~1.304)] were the main factors affecting adverse pregnancy outcomes in pregnant women with HBV infection (P<0.05). The sensitivity and specificity of HBV pgRNA and IP-10 in predicting adverse pregnancy outcomes were 78.30%, 65.20% and 91.30%, respectively, and 63.30%, 73.40% and 86.10%, respectively. Moreover, the combinatiob of HBV pgRNA and IP-10 had a high value in predicting adverse pregnancy outcomes in pregnant women with HBV infection (AUC of 0.895). Conclusion HBV pgRNA and IP-10 are associated with adverse pregnancy outcomes in pregnant women with HBV infection, and the combined prediction of adverse pregnancy outcomes has the high value.

Key words: Interferon γ inducible protein 10, HBV genomic RNA, Pregnancy, Pregnant women infected with hepatitis B virus, Pregnancy outcome