Chinese Hepatolgy ›› 2025, Vol. 30 ›› Issue (11): 1542-1545.

• Other Liver Diseases • Previous Articles     Next Articles

Epidemiological characteristics of liver transplantation patients at Beijing You’an Hospital from 2015 to 2023

WU Yu1,2, DUAN Xiao-wan3, XU Man-man1,2, WANG Wen-ling1,2, CHEN Yu1,2   

  1. 1. Fourth Department of Liver Disease, Beijing You′an Hospital, Capital Medical University, Beijing 100069, China;
    2. Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing 100069, China;
    3. Medical Insurance Office, Beijing You′an Hospital, Capital Medical University, Beijing 100069, China
  • Received:2024-11-09 Online:2025-11-30 Published:2026-02-09
  • Contact: CHEN Yu,Email:chybeyond1071@ccmu.edu.cn

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Abstract: Objective To explore the epidemiological characteristics and trends of liver transplantation, and to provide evidence-based medical data for the treatment and management of liver transplantation. Methods A retrospective analysis was conducted on the epidemiological data of patients who underwent liver transplantation at Beijing You′an Hospital from 2015 to 2023. The Man-Kendall trend test was used to analyze the annual changes in age, gender, length of hospital stay, indications for liver transplantation, and causes of liver disease. Results Among 1,118 liver transplant patients, 876 were male (78.4%). The average age was 52.1 years, with the majority of patients aged between 41 and 60 years. 678 patients (60.6%) came from outside Beijing. The average length of hospital stay was 26.5 days, which showed a significant yearly decrease (Z=-3.232, P=0.001). The main indications for liver transplantation were liver malignancies (46.5%) and decompensated cirrhosis (24.3%), followed by acute-on-chronic liver failure (15.2%) and chronic liver failure (6.2%). Acute/subacute liver failure accounted for 6.5%, showing a significant increasing trend over the years (Z=2.398, P=0.017). Hepatitis B remained the leading cause of chronic liver disease (55.5%), followed by alcoholic liver disease (17.7%), cryptogenic liver disease (8.1%), autoimmune liver disease (6.0%), and hepatitis B + alcoholic liver disease (5.8%). Longitudinal analysis revealed a decreasing trend in the proportion of hepatitis B (Z=-2.189, P=0.029), while the proportion of alcoholic liver disease showed a significant increasing trend (Z=2.819, P=0.005). Conclusion Males and individuals aged 41~60 years represent the main population for liver transplantation patients, with liver malignancies and decompensated cirrhosis as the primary indications. Although hepatitis B remains the major cause of chronic liver disease, its proportion has decreased annually, while alcoholic liver disease has shown a significant increase.

Key words: Liver transplantation, Epidemiology, Indications, Etiology