Abstract: Objective To investigate the efficacy and safety of cadronic acid disodium combined with local single radiotherapy in patients with hepatocellular carcinoma(HCC) with bone metastasis. Methods 68 HCC patients with bone metastasis admitted from January 2022 to March 2024 in Hai′an City People′s Hospital were randomly divided into an observation group and a control group. Based on routine intervention and single radiotherapy, the control group were treated with zoledronic acid, while the observation group were treated with infadronate disodium. The course of treatment was 2 months. The changes of bone metabolism, liver function, physiological indexes, efficacy and safety were observed. Results After 2 months of treatment, the serum 25-hydroxyvitamin D level in the observation group was (45.08±6.13) ng/mL, which was higher than that in the control group (40.27±5.26) ng/mL, the level of type I collagen crosslinked amino terminal peptide and serum bone-specific alkaline phosphatase were (22.93±2.75) ng/mL and( 92.76±7.81) U/L. Lower than (26.76±3.08) ng/mL and (98.54±8.36)U/L in control group, the differences were statistically significant (t=6.914, 6.237, 6.873, P<0.05). The levels of alanine aminotransferase, alkaline phosphatase and total bilirubin in the observation group were (68.42±6.18) U/L, (91.37±7.65) U/L and (17.35±2.07) μmol/L,lower than (74.29±6.84) U/L, (98.63±8.04) U/L, (18.47±2.13) μmol/L in control group, the differences were statistically significant (t=6.417, 6.527, 6.165, P<0.05). The scores of the pain scale and the bone metastases-specific subscale of the European Cancer Research and Treatment tissue in the observation group were (4.51±0.75) and (17.46±3.08) points, which were lower than those of the control group (4.97±0.84) and (19.38±3.25) points, and the core score of the quality of life scale for cancer patients was (66.59±5.71) points. It was higher than 61.84±5.47 points in the control group, and the differences were statistically significant (t=5.672, 6.385, 6.473, P<0.05). The objective remission rate of observation group was 67.65%, which was higher than that of control group (47.06%). The incidence of adverse reactions was 11.76%, which was lower than 26.47% in the control group, with statistical significance (χ²=3.296, 3.514, P<0.05). Conclusion Cadronic acid disodium combined with local single radiotherapy can improve the metabolism and liver function of HCC patients with bone metastasis and the quality of life.

Key words: Hepatocellular carcinoma, Bone metastasis, Infadronate disodium, Local single radiotherapy, Bone metabolism, Liver function