Efficacy of bifidobacterium tri-species probiotic combination with ganciclovir in the treatment of neonatal cytomegalovirus hepatitis

Abstract

Abstract: Objective To investigate the therapeutic effect of Bifidobacterium tri-species probiotics combined with ganciclovir in neonatal cytomegalovirus (CMV) hepatitis. Methods A total of 106 neonates diagnosed with CMV hepatitis were treated between January 2021 and January 2024 in Nanyang Central Hospital. They were subsequently randomized into two groups, comprising 53 patients in each.The control group received ganciclovir alone, while the observation group received Bifidobacterium tri-species probiotics in addition to ganciclovir. After 3 weeks of treatment, evaluations were performed. The time of symptom resolution was recorded. Adverse reactions during treatment were also documented. Results The time for symptom improvement in the observation group for scleral jaundice [(6.23±1.21)days, (4.97±0.89)days, (3.40±0.84)days, (3.31±0.69) days], with differences being statistically significant (P<0.05). Post-treatment, the observation group showed a significantly lower viral load of (8.93±1.08) copies/mL and a higher CD4⁺/CD8⁺ ratio of (2.03±0.41) compared to the control group, with statistical significance (P<0.05). Conclusion The combination of bifidobacterium tri-species probiotics and ganciclovir significantly enhances the therapeutic effect in neonates with CMV hepatitis.

Key words: Bifidobacterium tri-species probiotics, Ganciclovir, Cytomegalovirus hepatitis, Neonates

WANG Pin, ZHANG Jing, REN Ya-fang. Efficacy of bifidobacterium tri-species probiotic combination with ganciclovir in the treatment of neonatal cytomegalovirus hepatitis[J]. Chinese Hepatolgy, 2026, 31(3): 441-444.

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