The predictive value of the γ-glutamyl transferase/platelet ratio for the prognosis of patients with sepsis-related liver injury

Abstract

Abstract: Objective To explore the predictive value of the γ-glutamyl transferase (GGT)/platelet (PLT) ratio (GPR) for the prognosis of cases with sepsis-related liver injury (SRLI). Methods A total of 102 patients with SRLI from June 2022 to July 2024 in Chongming Hospital Affiliated to Shanghai Health Medical College were selected. They were divided into a good prognosis group (n=68) and a poor prognosis group (n=34) according to their 28-day prognosis after admission. GGT levels were detected by enzyme-linked immunosorbent assay, and PLT was detected by an automatic blood cell analyzer. GPR was calculated. The predictive value of GPR for the prognosis of SRLI patients was analyzed by receiver operating characteristic(ROC)curve. The influencing factors of the prognosis of SRLI cases were explored by multivariate logistic stepwise regression analysis. Results The GGT and GPR of the poor prognosis group were (76.84±10.23) U/L and (0.82±0.13), respectively, which were higher than those of the good prognosis group [(51.60±12.19) U/L and (0.43±0.10)]. The PLT of the poor prognosis group was (94.17±15.98) × 10⁹/L, which was lower than that of the good prognosis group [(121.29±17.24) × 10⁹/L] (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of GPR for predicting the prognosis of SRLI patients was 0.925, which was greater than that of GGT and PLT alone (0.832 and 0.778, respectively) (Z=9.475, 11.824, P<0.001). The proportion of patients with acute kidney injury, the proportion of patients with severe liver injury, APACHE Ⅱ score, SOFA score, and CRP in the poor prognosis group were 52.94%, 41.18%, (27.14±7.08) points, (15.03±3.01) points, and (25.83±4.37) mg/L, respectively, which were higher than those in the good prognosis group [32.25%, 14.70%, (18.29±5.76) points, (11.52±2.18) points, and (20.17±4.05) mg/L] (P<0.05). The severity of liver injury (OR=2.396, 95%CI: 1.308~4.391), APACHE Ⅱ score (OR=2.130, 95%CI: 1.328~3.416), SOFA score (OR=2.522, 95%CI: 1.303~4.882), and GPR (OR=2.998, 95%CI: 1.695~5.303) were independent factors associated with poor prognosis for the prognosis of SRLI patients (P<0.05). Conclusion GPR is an independent influencing factor for the prognosis of SRLI patients, and GPR showed good predictive value for the prognosis of SRLI patients.

Key words: γ-glutamyl transferase/platelet ratio, Sepsis, Liver injury, Prognosis, Predictive value

RONG Jin, CHENG Xi-yun, YIN Hong-min. The predictive value of the γ-glutamyl transferase/platelet ratio for the prognosis of patients with sepsis-related liver injury[J]. Chinese Hepatolgy, 2026, 31(5): 724-728.

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