Ox-LDL-induced ETs production of macrophages in patients with cirrhosis

Abstract

Abstract: Objective To investigate whether the oxidized low-density lipoprotein (ox-LDL) in cirrhosis patients induces macrophages to release extracellular traps (ETs) and promotes the development of cirrhosis.Methods Liver ultrasound and transient elastography were used to screen patients with cirrhosis. The formation of ETs was observed by stimulating macrophages with ox-LDL and other substances. Ox-LDL and ETs levels were detected. Phenotype transformation of macrophages was induced.Results Macrophages in healthy people did not release ETs with the stimulation of ox-LDL. Conversely, the ETs formation of macrophages in patients with cirrhosis was induced by the stimulation of ox-LDL, which reached its peak at 5 hours after stimulation. ETs induced the transformation of macrophages from phenotype M1 to M2.Conclusion Ox-LDL can induce macrophages to produce ETs in patients with cirrhosis, which may be related to the development mechanism of cirrhosis.

Key words: Extracellular traps, Macrophages, Liver cirrhosis, Oxidized low-density lipoprotein

MENG Qing-yang, XU Chun-lin, KANG Peng. Ox-LDL-induced ETs production of macrophages in patients with cirrhosis[J]. Chinese Hepatolgy, 2019, 24(9): 1007-1010.

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