Abstract: Objective To analyze the clinical and imaging features of 26 patients with hepatic sinusoidal obstruction syndrome (SOS), and to provide experience for clinical diagnosis and treatment of SOS. Methods The clinical data of 26 patients with SOS hospitalized in the Fifth Medical Center of Chinese People's Liberation Army General Hospital from November 2010 to February 2019 were analyzed retrospectively, symptoms and signs, laboratory examinations, imaging features and etiology were summarized. Results In 26 patients with SOS, abdominal distension, fatigue, anorexia and ascites were the main symptoms and signs. Of these patients, 1 after liver transplantation and 1 after renal transplantation had chemotherapy history, 1 patient was with unknown etiology, and the other 23 patients had a history of taking Chinese herbal medicine, among which the most had taken the gynura segetum (80.8%). Laboratory examinations showed that alanine aminotransferase (ALT) elevated in 17 cases, aspartate transaminase (AST) elevated in 20 cases, cancer antigen 125 (CA125) elevated in 23 cases. The imaging features of computed tomography and magnetic resonance were similar, including 11 cases of splenomegaly, 24 cases of ascitic fluid, 21 cases of uneven density and signal intensity of liver, 23 cases of inhomogeneous enhancement in enhanced scan, and 11 cases of thinner or unclear hepatic veins. Conclusion The main cause of SOS is taking gynura segetum, the clinical manifestations are abdominal distention, fatigue, anorexia, abnormal liver function and elevated CA125. The imaging features are hepatosplenomegaly, ascites, uneven liver density and signal, inhomogeneous enhancement of enhanced scanning and thinner or unclear hepatic veins.

Key words: Hepatic sinusoidal obstruction syndrome, Magnetic resonance imaging, Computed tomography