Abstract: Objective To investigate predictive value of hepatic hemodynamics ultrasonic parameters combined with peripheral blood von Willebrand factor antigen (vWF-Ag) for esophageal varices hemorrhage (EVH) in patients with liver cirrhosis.Methods From December 2015 to December 2018, 80 cases of cirrhosis, 80 cases of cirrhosis combined with EVH patients and 80 healthy individuals in our hospital were enrolled, and set as cirrhosis group, cirrhosis & EVH group, and control group, respectively. Various indexes were compared between groups, including hepatic hemodynamics ultrasonic parameters, as well as the serum vWF-Ag levels. The correlation of hemodynamics ultrasonic parameters and peripheral blood vWF-Ag level in cirrhosis combined with EVH patients was analyzed. Results Significant differences were found in the levels of PVD[(1.25±0.20), (1.52±0.25), (0.78±0.15)], PV-CI[(0.08±0.03), (0.13±0.03), (0.05±0.01)], PVAT[(19.88±4.59), (23.34±3.68), (13.19±3.02)], PVV[(18.13±4.38), (15.88±4.23), (20.20±4.16)], HVAT[(20.35±5.19), (16.77±2.66), (23.96±5.56)], IHCT[(9.53±2.55), (6.48±1.90), (11.12±2.93)], HV-DI[(0.62±0.12), (0.75±0.13), (0.51±0.11)] and serum vWF-Ag [(150.15±19.61), (211.09±50.83), (90.33±10.28)]in the 3 groups cirrhosis group, cirrhosis & EVH group, and control group (P<0.05). With the increase of the EVH severity (mild, moderate, severe), the levels of PVD[(1.38±0.08), (1.50±0.16), (1.61±0.23)], PV-CI[(0.12±0.04), (0.14±0.03), (0.16±0.05)], HV-DI[(0.72±0.09), (0.78±0.12), (0.84±0.15)], PVAT[(21.11±3.01), (23.45±4.23), (25.67±4.92)]and serum vWF-Ag[(206.45±35.43), (225.32±50.67), (256.30±59.62)]in patients with cirrhosis were increased, meanwhile, the PVV[(16.88±3.48), (14.33±2.12), (12.56±1.87)], HVAT[(18.45±2.68), (16.34±2.22), (13.26±1.08)]and IHCT[(6.29±1.76), (6.01±1.46), (5.91±1.03)]were decreased (P<0.05). Serum vWF-Ag levels in patients with cirrhosis and EVH were positively correlated with PVD, PV-CI, HV-DI and PVAT (P<0.05), and negatively correlated with PVV, HVAT and IHCT (P<0.05). The diagnostic efficacy of hepatic hemodynamics ultrasonic parameters combined with vWF-Ag in patients with cirrhosis with EVH was significantly better than single detection (P<0.05).Conclusion Predictive value of hepatic hemodynamics ultrasonic parameters combined with peripheral blood vWF-Ag is certain for cirrhosis combined with EVH patients, which is worthy of clinical promotion.

Key words: Hepatic hemodynamics ultrasonic parameters, vWF-Ag, Cirrhosis of the liver, Esophageal variceal hemorrhage, Predictive value