Table of Content

28 February 2018, Volume 23 Issue 2

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Original Articles

The dynamic changes of HBsAg, HBeAg and HBV DNA levels and their correlation with HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients with long-term nucleos(t)ide analogues treatment

FU Wei-jia, LI cheng-zhong.

2018, 23(2):  114-117. 

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Objective To investigate the dynamic changes of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA in HBeAg-positive chronic hepatitis B (CHB) patients with long-term treatment of nucleos(t)ide analogues, and to analyze their correlations with HBeAg seroconversion.Methods Clinical data of 439 HBeAg-positive CHB patients with 4-year follow-up was retrospectively analyzed. Results At baseline, HBsAg was positively correlated with HBeAg and HBV DNA, and HBeAg was weakly positively correlated with HBV DNA in HBeAg-positive CHB patients. After 4-year antiviral therapy, levels of HBsAg, HBeAg and HBV DNA were significantly decreased. Higher HBsAg decline rate in the first 6 months and lower levels of HBsAg and HBeAg at baseline showed higher possibility of HBeAg serum response (SR) rate. Among the HBeAg-positive CHB patients, there were 31.44% acheiving HBeAg SR, including 28.65% with entecavir treatment, 50.34% with telbivudine, 48.39% with telbivudine + adefovir, 9.09% with entecavir + adefovir and 10.13% with lamivudine + adefovir.Conclusion Patients with higher HBsAg decline rate in the initial 6 months of antiviral therapy, as well as lower levels of HBsAg and HBeAg at baseline, might have the higher possibility to acheive HBeAg SR.

Helicobacter pylori infection as a protective factor for glue extrusion bleeding

LIN Yi-jun, MA Jia-li, ZHOU Yu-lin, HU Ju-long, LIANG Xiu-xia, LI Ping.

2018, 23(2):  118-120. 

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Objective To investigate the relationship between glue extrusion bleeding and helicobacter pylori (Hp) infection.Methods The a retrospective study enrolled 524 patients with endoscopic tissue adhesive injection in our hospital from October 2008 to June 2017.including 64 cases of glue extrusion bleeding group and 460 cases of non-bleeding group. Hp infection rate was compared between the two groups. Results There were 430 Hp positive patients with infection rate of 82.06%, 64 patients suffering glue extrusion bleeding with an incidence rate was of 12.21%. The Hp infection rate in non-bleeding group was significantly higher than that in bleeding group (P=0.00). Hp infection was not a risk factor for glue extrusion bleeding (P=0.130).Bleeding rate was higher in patients with poor liver reserve function.Conclusion Hp infection might be a protective factor for patients with gastric variceal who underwent endoscopic tissue adhesive injection. Additionally,the glue extrusion bleeding incidence has a positive correlation with Child-Pugh score.

MRI analysis of hepatic epithelioid hemangioendothelioma

REN Hong-wei, AN Wei-min, LIU Yuan, DONG Jing-hui.

2018, 23(2):  121-124. 

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Objective To investigate the magnetic resonance imaging (MRI) characteristics and pathological features of hepatic epithelioid hemangioendothelioma (HEHE).Methods MRI characteristics and clinical data of 8 patients with pathologically diagnosed HEHE from March 2012 to May 2017 were retrospectively analyzed. All patients underwent MRI scan. MRI performance and the related pathology were analyzed by 2 senior physicians. Results All 8 HEHE cases manifested as multiple intrahepatic lesions, including 3 cases with lung metastasis and 1 case with both lung and vertebral metastasis. MRI revealed that intrahepatic lesions were hypointense on T1 weighted imaging but hyperintense on T2 weighted imaging. In dynamic contrast-enhancement, lesions showed progressive or ring enhancements. Signs of hepatic capsular traction and lollipop were also observed.Conclusion HEHE has some special MRI characteristics, which is still further confirmed by the pathology.

Expression of chemokine ligand-18 in hepatocellular carcinoma and its influence on the clinicopathological features and prognosis

WU Xu-bo, CHANG Qi-meng, WANG Jian-fa, HU Zhi-qiu, SHEN Xiao-dong, ZHANG Zi-ping.

2018, 23(2):  125-127. 

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Objective To investigate the expression and clinical significance of chemokine ligand-18 (CCL18) in hepatocellular carcinoma (HCC).Methods Forty patients with HCC in our hospital were enrolled. Normal liver tissues adjacent to HCC, as well as normal liver tissues resected from benign liver lesions, were selected as controls. Hepatic expression of CCL18 were detected using immunohistochemistry, and its relationship with clinicopathological features was analyzed. Effect of CCL18 on prognosis of HCC was analyzed using Kaplan-Meier method. Results The positive expression rates of CCL18 in HCC tissues, paracancerous tissues and normal liver tissues were 72.5%, 7.5% and 5.0%, respectively. CCL18 expression significantly increased in patients with poor pathological differentiation and metastasis. The progression-free survival and overall survival in CCL18 negative expression group were significantly higher than those in the positive expression group (P<0.05).Conclusion The positive expression rate of CCL18 was significantly higher in HCC than that in control cases, and closely related to the prognosis. HCC patients with negative hepatic CCL18 might have a longer survival.

STAT3 aggravates TGF-β1 induced epithelial-to-mesenchymal transition in hepatocellular carcinoma cells

LIU Ting, WU Jun-cheng, LU Lun-gen, XU Ming-yi.

2018, 23(2):  128-132. 

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Objective To investigate the underlying molecular mechanisms of interleukin-6/Janus kinase/ signal transducer and activator of transcription (IL-6/JAK/STAT3) and Smad3/transforming growth factor-β1 (Smad3/TGF-β1) signaling pathways during the epithelial to mesenchymal transition (EMT) process in hepatocellular carcinoma (HCC) cells.Methods Human HCC cell lines HepG2 and HCCLM3 were treated with TGF-β1, AG490 and IL-6, respectively. mRNA expressions of STAT3 and Snail were measured using quantitative PCR. Expressions of p-STAT3/STAT3, p-Smad3/Smad3, TGF-β1 and EMT-related markers were measured using western blotting. Results TGF-β1 induced EMT in HepG2 cells, dampen E-Cadherin expression and up-regulate expressions of vimentin, Snail, p-Smad2/3 and p-STAT3/STAT3. IL-6 activated Smad3/TGF-β1 pathway by stimulating STAT3 in human HCC lines, and up-regulated expressions of EMT-related molecular markers (Snail and Vimentin). AG490, the JAK2-specific inhibitor, inhibited expressions of p-STAT3/STAT3, p-Smad3 and Snail.Conclusion STAT3 aggravated TGF-β1-induced EMT and HCC metastasis, which performed a synergistical effect with IL-6/JAK/STAT3 and Snail/Smad3/TGF-β1 signaling pathways.