Abstract: Objective To explore the different clinical features of liver injury induced by traditional Chinese medicine and western medicine,and to provide evidences for pro Moting clinical rational drug use and avoiding drug-induced liver injury（DILI）. Methods Three hundred and twenty-eight patients with primary diagnosis of DILIwere assessed by Roussel Claf causality assessment method Roussel Uclaf Causality Assessment Method（RUCAM）rating system,274 of which with scores≥6 were enrolled in this study for comparison of occurrence,clinical features and risk factors between traditional Chinese medicines and western medicine induced liver injury. Results Ratio of traditional Chinese medicine and western medicine induced liver injury was 1:2.22,in which male/female ratio was 1:1.74 and 1:0.77,respectively. Besides,main drugs of western and traditional Chinese medicine due to DILIwere anti-tuberculosis drugs and polygonu MMultifloru m,respectively. Levels of alanine aminotransferase（ALT）,total bilirubin（TBiL）,aspartate transaminase （AST）,gam ma-glutam yl transpeptidase（GGT）and alkaline phosphatase（ALP）in traditional Chinese group were Much higher than those in western medicine group. Furtherm ore,levels of ALTand TBiLshowed statistically significant difference（P<0.0001,P<0.018,respectively）between the 2 groups. The prognosis of DILIwas related to hospitalization days and levels of ALT,ASTand ALP.In addition,hepatitis Bvirus（HBV）infection was a risk factor of severe DILI（P=0.022）. Conclusion Traditional Chinese drug induces liver injury More frequently than western medicine does,even causes serious liver damage,which should be paid More attention to. Levels of ALT,ASTand ALPat first diagnosis are significant predictors for prognosis.

Key words: Drug-induced liver injury, Clinical features, Prognostic analysis