Abstract: Objective To investigate the differential diagnosis value of ultrasonic contrast for focal liver lesions. Methods One hundred and ten patients, which were pathologically diagnosed as focal liver lesions from May 2014 to December 2015 in our hospital, were enrolled, and their clinic data and ultrasonic contrast results were retrospectively analyzed. Results Based on the pathological diagnosis, the diagnostic accuracy of contrast-enhanced ultrasound in benign and malignant liver lesions were 97.5% and 96%, respectively (P>0.05). The enhanced time, peak time and regression time of contrast-enhanced ultrasound were longer in benign lesions than those in malignant lesions (P<0.05). There were 114 focal liver lesions detected in all those patients, containing 47 intrahepatic cholangiocarcinoma lesions with sonogram as fast-in and fast-out, 5 hepatocellular carcinoma as fast-in and slow-out, 22 hepatic metastasis as fast-in and fast-out, 20 vascular liver cancer as fast-in and fast-out, 7 cirrhotic nodules as fast-in and fast-out, 8 focal fatty liver as same-in and same-out, 2 focal nodular hyperplasia as fast-in and slow-out, and 3 liver abscess as fast-in and fast-out. Conclusion Ultrasonic contrast in differential diagnosis of benign and malignant focal liver lesion showed high accuracy, and could clearly reflect the sonogram characteristics of various lesions, which was worthy of popularization and application.

Key words: Contrast-enhanced ultrasonography; Focal liver lesions; Diagnosis