Local tumor progression after ultrasound-guided radiofrequency ablation for hepatocellular carcinoma: risk factors analysis

Abstract

Abstract: Objective To investigate the risk factors for local tumor progression (LTP) after ultrasound-guided radiofrequency ablation (RFA) in treatment of hepatocellular carcinoma (HCC).Methods Ninety-nine patients with 107 lesions involved in this study received RFA for HCC. Contrast-enhanced ultrasound (CEUS) perfusion parameters, liver stiffness measurement (LSM) and other examinations in all those patients were collected at a mean follow-up of 10.6 months. Kaplan-Meier model, log-rank test and Cox proportional hazard model was applied for survival analysis and identifying risk factors for LTP in HCC patients after RFA.Results Tumor size, distance to large vessels, tumor perfusion and LSM were independent risk factors for LTP with the hazard ratios (HR) as 1.12, 1.38, 1.59 and 1.77, respectively. Additionally, transarterial chemoembolization (TACE) before RFA treatment was a protective factor for LTP (HR 0.52).Conclusion Tumor size, distance to large vessels, tumor perfusion and LSM are the most important risk factors for LTP after RFA. Besides, using TACE before RFA treatment can effectively improve LTP.

Key words: Hepatocellular carcinoma, Radiofrequency ablation, Ultrasound, Local tumor progression

LI Meng LI Zhi-yan GAO Yue-juan ZHANG Da-kun DONG Jing-hui TANG Yu TIAN Jiang-ke. Local tumor progression after ultrasound-guided radiofrequency ablation for hepatocellular carcinoma: risk factors analysis[J]. Chinese Hepatolgy, 2017, 22(2): 104-107.

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